Demir Karboksimaltoz Tedavisi Sonrası Hipofosfatemi Sıklığı: Tek Merkez Deneyimi

Amaç: Demir karboksimaltoz (DKM) infüzyonu sonrası hipofosfatemi sıklığını ve hipofosfatemiye etki eden faktörleri değerlendirmek amaçlanmıştır. Gereç ve Yöntem: Demir eksikliği anemisi (DEA) nedeniyle DKM tedavisi alan 92 hasta çalışmaya alındı. DKM öncesi ve sonrası fosfor, kalsiyum, magnezyum, 25-hidroksi vitamin D, parathormon seviyeleri dosya bilgilerinden kaydedildi. Hipofosfatemi serum fosfor düzeyinin

Incidence of Hypophosphatemia after Ferric Carboxymaltose Treatment: Single Center Experience

Aim: The aim of this study was to evaluate the incidence of hypophosphatemia after ferric carboxymaltose (FCM) infusion and the factors affectinghypophosphatemia.Materials and Methods: Ninety-two patients who received FCM treatment for iron deficiency anemia (IDA) were included in the study. Phosphorus,calcium, magnesium, 25-hydroxy vitamin D, and parathyroid hormone levels before and after FCM infusion were obtained from the medical records.Hypophosphatemia was defined as serum phosphorus level of

___

  • 1. World Health Organization. Iron Deficiency Anaemia Assessment, Prevention, and Control. A guide for programme managers. Switzerland: World Health Organization; 2001.
  • 2. World Health Organization. The global prevalence of anaemia in 2011. Geneva: World Health Organization; 2015.
  • 3. Cancelo-Hidalgo MJ, Castelo-Branco C, Palacios S, Haya-Palazuelos J, Ciria-Recasens M, Manasanch J, et al. Tolerability of different oral iron supplements: a systematic review. Curr Med Res Opin. 2013;29:291-303.
  • 4. Gereklioglu C, Asma S, Korur A, Erdogan F, Kut A. Medication adherence to oral iron therapy in patients with iron deficiency anemia. Pak J Med Sci. 2016;32:604-7.
  • 5. Qunibi WY. The efficacy and safety of current intravenous iron preparations for the management of iron-deficiency anaemia: a review. Arzneimittelforschung. 2010;60:399-412.
  • 6. Emrich IE, Lizzi F, Siegel JD, Seiler-Mussler S, Ukena C, Kaddu-Mulindwa D, et al. Hypophosphatemia after high-dose iron repletion with ferric carboxymaltose and ferric derisomaltose-the randomized controlled HOMe aFers study. BMC Med. 2020;18:178.
  • 7. Wolf M, Rubin J, Achebe M, Econs MJ, Peacock M, Imel EA, et al. Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron- Deficiency Anemia: Two Randomized Clinical Trials. JAMA. 2020;323:432- 43.
  • 8. Wolf M, Chertow GM, Macdougall IC, Kaper R, Krop J, Strauss W. Randomized trial of intravenous iron-induced hypophosphatemia. JCI Insight. 2018;3:e124486.
  • 9. World Health Organization, Worldwide Prevalance of Anemia 1993- 2005. WHO Global Database on Anaemia. Switzerland: World Health Organization; 2008.
  • 10. Short MW, Domagalski JE. Iron deficiency anemia: evaluation and management. Am Fam Physician. 2013;87:98-104.
  • 11. World Health Organization, International statistical classification of diseases and related health problems. - 10th revision, World Health Organization Geneva, Switzerland: 2016.
  • 12. Cançado RD, Muñoz M. Intravenous iron therapy: how far have we come? Rev Bras Hematol Hemoter. 2011;33:461-9.
  • 13. Bregman DB, Goodnough LT. Experience with intravenous ferric carboxymaltose in patients with iron deficiency anemia. Ther Adv Hematol. 2014;5:48-60.
  • 14. Glaspy JA, Lim-Watson MZ, Libre MA, Karkare SS, Hadker N, Bajic-Lucas A, et al. Hypophosphatemia Associated with Intravenous Iron Therapies for Iron Deficiency Anemia: A Systematic Literature Review. Ther Clin Risk Manag. 2020;16:245-59.
  • 15. Hardy S, Vandemergel X. Intravenous iron administration and hypophosphatemia in clinical practice. Int J Rheumatol. 2015;2015:468675.
  • 16. Hanudel MR, Laster M, Salusky IB. Non-renal-Related Mechanisms of FGF23 Pathophysiology. Curr Osteoporos Rep. 2018;16:724-9.
  • 17. Imel EA, Liu Z, McQueen AK, Acton D, Acton A, Padgett LR, et al. Serum fibroblast growth factor 23, serum iron and bone mineral density in premenopausal women. Bone. 2016;86:98-105.
  • 18. Ifie E, Oyibo SO, Joshi H, Akintade O. Symptomatic hypophosphataemia after intravenous iron therapy: an underrated adverse reaction. Endocrinol Diabetes Metab Case Rep. 2019;2019:19-0065.
  • 19. Callejas-Moraga EL, Casado E, Gomez-Nuñez M, Caresia-Aroztegui AP. Severe osteomalacia with multiple insufficiency fractures secondary to intravenous iron therapy in a patient with Rendu-Osler-Weber syndrome. Bone Rep. 2020;13:100712.
  • 20. Fang W, McMahon LP, Bloom S, Garg M. Symptomatic severe hypophosphatemia after intravenous ferric carboxymaltose. JGH Open. 2019;3:438-40.
Namık Kemal Tıp Dergisi-Cover
  • ISSN: 2587-0262
  • Yayın Aralığı: 4
  • Başlangıç: 2013
  • Yayıncı: Galenos Yayınevi
Sayıdaki Diğer Makaleler

Metastatik Beyin Tümörlerinin Mikrocerrahi Yönetiminde Sodyum Fluorescein Boyamanın Cerrahi Sonuçlara Etkileri

Tamer TUNÇKALE, Tezcan ÇALIŞKAN

HER2 Pozitif Meme Kanserinde Neoadjuvan Tedaviye Patolojik Yanıtı Belirleyen Klinikopatolojik Faktörler

Semra PAYDAŞ, Abdullah Evren YETİŞİR

Incidence of Hypophosphatemia after Ferric Carboxymaltose Treatment: Single Center Experience

Esra TERZİ DEMİRSOY

Cerrahi Birimlerde Çalışan Hemşirelerin İzolasyon Önlemlerine Uyumunda Eğitimin Etkisi

Tülin YILDIZ, Emine KARAGÜLLE KOZA

The Effect of Rosmarinic Acid on Cell Viability, Steatosis, Paraoxonase-1, and Paraoxonase-3 Protein Levels in Palmitateinduced Non-alcoholic Fatty Liver Disease Model in HepG2 Cells

Esra YAKŞİ, ERAY ÖZGÜN

Is the Optimal Timing First Complete Remission for Autologous Stem Cell Transplantation in Patients with Peripheral T-Cell Lymphoma?

Bahar ULU, Derya ŞAHİN, Tuğçe Nur YİĞENOĞLU, Merih KIZIL ÇAKAR, Mehmet DAL, Fevzi ALTUNTAŞ

Periferik T Hücreli Lenfoma Hastarında Otolog Kök Hücre Nakli için Uygun Zamanlama İlk Tam Remisyon mudur?

Fevzi ALTUNTAŞ, Bahar UNCU ULU, Mehmet Sinan DAL, Tuğçe Nur YİĞENOĞLU, Derya ŞAHİN, Merih KIZIL ÇAKAR

Evaluation of the Hearing System in Chronic Obstructive Pulmonary Disease Patients

Oral Burak DEMİREL, Tolga ERSÖZLÜ, Mahmut DENİZ

Diabetes Mellitus Tanılı İnsülin Kullanan Geriatrik Hastalarda Tedaviye Uyum ve Kırılganlık Arasındaki İlişki

Okcan BASAT, Sema BASAT, Mevlüt KIYAK, Mustafa Behçet DEMİRBAŞ, Imantay SHAUYET, Rıdvan SİVRİTEPE, Gamze GEYİK YÜNOĞLU, Selda ÇAKIN ÜNNÜ

Distribution and Characterization of Aeroallergens in the Etiology of Allergic Rhinitis Patients in İstanbul Kartal Region

Kadriye TERZİOĞLU, Meltem AĞCA