Demir Eksikliği Anemisi ve Serum Ferritin Düzeyi ile İlgili Maternal ve Neonatal Sonuçlar: Doğu Marmara Bölgesine Ait Çok Merkezli Bir Prospektif Çalışma, Türkiye

Amaç: Bu çalışmanın amacı, demir takviyesi ve demir durumunun maternal ve neonatal etkileri ile birlikte Türkiye'nin Doğu Marmara bölgesinde gebelikte görülen demir eksikliği anemisi insidansını değerlendirmektir. Materyal ve Metot: Bu çalışma Doğu Marmara Bölgesi'nin (Türkiye) üç ilinde altı merkezde gerçekleştirilmiş ve toplam 1102 gebeyi kapsamıştır. Gebelik sırasında hematolojik durum ve serum ferritin düzeyleri için kan örnekleri toplandı ve olumsuz maternal ve perinatal sonuçlar belirlendi. Demir eksikliği anemisi, Dünya Sağlık Örgütü kriterlerine göre hemoglobin

MATERNAL AND NEONATAL OUTCOMES RELATED TO IRON DEFICIENCY ANEMIA AND SERUM FERRITIN STATUS: A MULTICENTER PROSPECTIVE STUDY FROM EASTERN MARMARA, TURKEY

Aim: The aim was to evaluate the incidence of iron deficiencyanemia in pregnancy in the East Marmara region of Turkey in orderto determine its prevalence along with the effects and associationsof iron supplementation on maternal and neonatal outcomes.Materials and Methods: This study was conducted in sixcenters and included a total of 1102 pregnant women.Blood samples were collected for hematological status andserum ferritin levels during pregnancy, and the adversematernal and perinatal outcomes were determined. Irondeficiency anemia was diagnosed according to the WorldHealth Organization criteria as hemoglobin level of < 11g/dl and ferritin level of

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  • 1. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: A systematic analysis of population-representative data. The Lancet Global Health,1(1), e16-e25.
  • 2. WHO, Unicef. UNU. (2001). Iron deficiency anaemia: assessment, prevention and control, a guide for programme managers. Geneva: World Health Organization.
  • 3. Stoltzfus RJ, Mullany L, Black RE. Iron deficiency anaemia. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL, editors. Comparative quantification of health risks: Global and regional burden of disease attributable to selected major risk factors. Geneva: World Health Organization; 2004,1: 163–209.
  • 4. Clark SF. Iron deficiency anemia. Nutr Clin Pract 2008;23 (2):128–41.
  • 5. Scholl TO. Maternal iron status: relation to fetal growth, length of gestation, and iron endowment of the neonate. Nutr Rev 2011; 69 (suppl-1): 23–9.
  • 6. Balarajan Y, Ramakrishnan U, Ozaltin E, et al. Anaemia in lowincome and middle-income countries. Lancet 2011;378.9809: 2123–35.
  • 7. de Sa SA, Willner E, Duraes Pereira TA, et al. Anemia in pregnancy: Impact on weight and in the development of anemia in newborn. Nutr Hosp 2015;32 (5):2071–9.
  • 8. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, et al. Diagnosis and management of iron deficiency anaemia: A clinical update. Med J Aust 2010;193 (9) :525–32.
  • 9. Pfeiffer CM, Looker AC. Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr 2017; 106 (supply-6) : 1606–14.
  • 10. Mei Z, Cogswell ME, Parvanta I, Lynch S, Beard JL, Stoltzfus RJ, Grummer-Strawn LM. Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: An analysis of nine randomized controlled trials. J Nutr 2005;135(8):1974–80.
  • 11. World Health Organization. (2011). Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations. No. WHO/NMH/NHD/MNM/11.2. World Health Organization.
  • 12. American College of Obstetricians and Gynecologists.Exercise during pregnancy and the postpartum period. Clinical obstetrics and gynecology, 2003, 46.2: 496.
  • 13. World Health Organization. (1999). Definition, diagnosis and classification of diabetes mellitus and its complications : report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. World Health Organization.
  • 14. Gardosi J, Mongelli M, Wilcox M, Chang A. An adjustable Fetal Weight Standard. Ultrasound Obstet Gynecol 1995;6(3) :168–74.
  • 15. . World Health Organization. (2015). The global prevalence of anaemia in 2011.
  • 16. Pinho-Pompeu M, Surita FG, Pastore DA, Paulino DSM, Pinto E, Silva JL. Anemia in pregnant adolescents: Impact of treatment on perinatal outcomes. J Matern Fetal Neonatal Med 2017;30(10): 1158-62.
  • 17. Bencaiova G, Breymann C. Mild Anemia and Pregnancy Outcome in a Swiss Collective. Journal of Pregnancy 2014; 2014:307535.
  • 18. Gambling L, Kennedy C, McArdle HJ. Iron and copper in fetal development. Seminars in Cell and Developmental Biology 2011;22(6):637–44.
  • 19. Kemper AR, Fan T, Grossman DC, Phipps MG. Gaps in evidence regarding iron deficiency anemia in pregnant women and young children: Summary of US Preventive Services Task Force recommendations. Am J Clin Nutr 2017; 106(suppl-6): 1555-58.
  • 20. World Health Organization. Guideline, W. H. O. (2012). Daily iron and folic acid supplementation in pregnant women. Geneva: World Health Organization, 27.
  • 21. Pena-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev 2012; 12: CD004736.
  • 22. Ziaei S, Norrozi M, Faghihzadeh S, Jafarbegloo E. A randomised placebocontrolled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin or = 13.2 g/dl. BJOG 2007; 114(6):684–8.
  • 23. Shastri L, Mishra PE, Dwarkanath P, Thomas T, Duggan C, Bosch R, et al. Association of oral iron supplementation with birth outcomes in non-anaemic South Indian pregnant women. Eur J Clin Nutr 2015;69(5):609–13.
  • 24. Frenkel EP, Yardley DA. Clinical and laboratory features and sequelae of deficiency of folic acid (folate) and vitamin B12 (cobalamin) in pregnancy and gynecology. Hematol Oncol Clin North Am 2000;14(5):1079-1100.
  • 25. Ramakrishnan U, Grant FK, Goldenberg T, Bui V, Imdad A, Bhutta ZA. Effect of multiple micronutrient supplementation on pregnancy and infant outcomes: A systematic review. Paediatric and Perinatal Epidemiology 2012; 26(suppl.1): 153–67.
  • 26. Weekly iron and folic acid supplementation programmes for women of reproductive age: An analysis of best programme practices. Manila, World Health Organization Regional Office for the Western Pacific, 2011.
  • 27. lanco-Rojo R, Perez-Granados AM, Toxqui L, Zazo P, de la Piedra C, Vaquero MP. Relationship between vitamin D deficiency, bone remodelling and iron status in iron-deficient young women consuming iron-fortified food. Eur J Nutr 2013;52(2):695–703.
  • 28. Sim JJ, Lac PT, Liu IL, Meguerditchian SO, Kumar VA, Kujubu DA, Rasgon SA. Vitamin D deficiency and anemia: A cross-sectional study. Ann Hematol 2010;89(5):447–52.
  • 29. Alon DB, Chaimovitz C, Dvilansky A, Lugassy G, Douvdevani A, Shany S, Nathan I. Novel role of 1,25(OH)(2)D(3) in induction of erythroid progenitor cell proliferation. Exp Hematol 2002;30(5):403–9.
  • 30. Bacchetta J, Zaritsky JJ, Sea JL, Chun RF, Lisse TS, Zavala K, Nayak A, Wesseling-Perry K, Westerman M, Hollis BW, et al. Suppression of iron-regulatory hepcidin by vitamin D. J Am Soc Nephrol2014;25(3):564–72.
Namık Kemal Tıp Dergisi-Cover
  • ISSN: 2587-0262
  • Başlangıç: 2013
  • Yayıncı: Erkan Mor
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