Hüseyin ÇETİN, Sabah Tüzün, Emel AHISHALI, Tuğba ARSLAN KÜÇÜK, Can DOLAPÇIOĞLU, Mustafa Reşat DABAK

İrritabl Barsak Sendromu ve Laktoz İntolerans Arasındaki İlişki

Amaç: İrritabl barsak sendromu (İBS) ve laktoz intoleransı (Lİ) birlikte görülebilmekte ve aynı zamanda benzer semptomlara neden olabildiği için sıklıkla karışabilmektedir. Bu çalışmada Roma III kriterlerine göre İBS tanısı alan hastalarda ve sağlıklı bireylerde Lİ’nin sıklığı ve İBS ile Lİ ilişkisinin incelenmesi amaçlanmaktadır. Materyal ve Metot: Çalışmaya Haziran-Aralık 2013 tarihleri arasında başvuran 18 – 80 yaş arasındaki hastalar dahil edilmiştir. İBS grubundaki hastalar Roma III kriterlerine göre İBS tanısı konan hastalardan oluşmakta olup, İBS alt tipleri değerlendirilmiştir. Çalışmanın kontrol grubuna ise İBS benzeri şikayetleri olmayan, 18 yaş ve üzerindeki sağlıklı gönüllüler dahil edilmiştir. Tüm katılımcılara 8 saat açlık sonrası 250 ml suda çözündürülen 25 gr laktoz 5 dk’da içirilerek hidrojen nefes testi (0, 15, 30, 60, 90, ve 120 dakikada) ile Lİ değerlendirilmiştir. Bulgular: Çalışmadaki toplam 200 katılımcının 100 (%50.0)’i İBS grubuna ve 100 (%50.0)’i kontrol grubuna dahil edildi. Katılımcıların toplam 70 (%35.0)’inde Lİ mevcut iken İBS grubunda katılımcıların 47 (%47.0)’inde ve kontrol grubundaki katılımcıların 23 (%23.0)’ünde Lİ saptanmıştır (p=0.001). İBS ile ilgili semptomlar her iki grupta Lİ olan katılımcılarda daha yaygın olarak saptanmıştır (sırasıyla, p=0.001 ve p=0.001). Sonuç: İBS hastalarında Lİ kontrol grubuna göre anlamlı yüksek bulunmuştur. Ayrıca, laktoz alımına bağlı semptomlar istatistiksel anlamlı olmamakla beraber İBS grubunda daha sık saptanmıştır.

THE ASSOCIATION BETWEEN IRRITABLE BOWEL SYNDROME AND LACTOSE INTOLERANCE

Aim:Irritable bowel syndrome (IBS) and lactose intolerance (LI) may co-exist and readily cause diagnostic confusion due to similar symptomatology. This study aims to examine the frequency of LI in healthy controls and in participants diagnosed with IBS based on Roma III criteria, as an effort to investigate the association between IBS and LI.Materials and Methods:The patient population consisted of individuals between 18 and 80 years of age who attended between June-December 2013. Patients diagnosed with IBS based on Roma III criteria comprised the IBS group, and subtypes of IBS. Control group was healthy volunteers over 18 years of age with no IBS-like symptoms. All participants ingested 25 g of lactose dissolved in 250 ml of water within 5 minutes after 8 hours of fasting, in order to evaluate the LI via hydrogen breath test (0, 15, 30, 60, 90, and 120 minutes).Results:Of the total 200 participants, 100 (50%) were in the IBS group and 100 (50.0%) were in the control group. Of the total 70 patients (35.0%) with LI, 47 (47.0%) were in the IBS group and 23 (23.0%) were in the control group (p=0.001). Symptoms related to IBS were more common in participants with LI in both groups (p=0.001, p=0.001 respectively).Conclusion:A significantly increased frequency of LI was found among IBS patients than in controls. In addition, symptoms associated with lactose intake occurred at a higher frequency in IBS patient, although the difference wasinsignificant.

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