NAZAL KAVİTE YERLEŞİMLİ RENAL HÜCRELİ KARSİNOM METASTAZI
Renal hücreli karsinom, erişkin neoplazilerinin %3’ünü oluşturan agresif bir tümördür. En sık metastaz yaptığı yerler akciğer, adrenal, barsak, beyin ve intraabdominal organlardır. Bunun yanı sıra literatürde kalp, mesane, meme, tonsil ve tiroide yerleşen metastaz olguları bildirilmiştir. Bu yazıda bir nazal kavite yerleşimli renal hücreli karsinom metastazı olgusunu, nazal obstrüksiyon ve epistaksis görülen ve renal hücreli karsinomu olan hastalarda metastaz olasılığının akılda tutulmasını vurgulamak amacıylasunduk.
Renal Cell Carcinoma Metastasis with Nasal Cavity
Renal cell carcinoma is an aggressive tumor that accounts for 3% of adult neoplasia. The most common sites of metastasis are the lung, adrenal, large intestine, brain and intraabdominal organs. In addition, cases of metastasis in the heart, bladder, breast, tonsil and thyroid have been reported in the literature. We present a case of renal cell carcinoma metastasis located in a nasal cavity in order to emphasize the possibility of metastatic lesions being responsible for nasal obstruction and epistaxis.
___
- 1. Sountoulides P, Metaxa L, Cindolo L. Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports. J Med Case Rep. 2011;5:429. 2. Siegel R, Miller K,Jemal A: Cancer statistics, CA Cancer J Clin. 2015; 65(1):5–29. 3. Mahajan R, Mayappa N, Prashanth V. Metastatic Renal Cell Carcinoma Presenting as Nasal Mass: Case Report and Review of Literature.. Indian J Otolaryngol Head Neck Surg July–Sept 2016; 68(3):374–6. 4. 4. Novara G, Ficarra V, Antonelli A, Artibani W, Bertini R, Carini M et al. Validation of the 2009 TNM version in a large multi, institutional cohort of patients treated for renal cell carcinoma: are further improvements needed? Eur Orol.2010;58(4):588-95. 5. Türk A, Aslan H, Balaban M, Demırkol MK, TarhanF.Böbreğin renal hücreli kanserlerinde klinik ve histopatolojik özellikler. J Kartal TR. 2014;25(2):124-6. 6. Danic P, Danic D, Macan D. Tongue metastasis as an initial presentation of renal cell carcinoma. Medicinski Glasnik. 2018;15(1):52-8. 7. Flanigan RC, Campbell SC, Clark JI, Picken MM. Metastatic renal cell carcinoma. Curr Treat Options Oncol.2003;4(5):385-90. 8. Kotak A, Merrick G. Presentation of metastatic renal cell carcinoma as a lip lesion. J Surg Case Rep 2014;2014(9):pii: rju083. 9. 9. Shaha S, Vinodb P, Khayatab M, Lanec JL, Hegded V, Rainae R. Atrial Metastasis of Renal Cell Carcinoma: A Rare Presentation. Cardiol Res. 2018;9(3):183-5. 10. Matsumoto K, Hayakawa N, Nakamura S, Oya M. Bladder metastasis from renal cell carcinoma: retrospective analysis of 65 reported cases. Clin Exp Metastasis.2015;32(2):135–41. 11. Kitaharaa M, Hozumia Y, Asadaa R, Sawaa A, Saitob H, Iijima T. Intramammary Metastasis in a Patient with a History of Renal Cell Carcinoma : A Case Report. Case Rep Oncol.2018;11(2):318–22. 12. Serouya SM, Dultz LA, Concors SJ, Wang B, Patel KN. Late solitary metastasis of renal cell carcinoma to the submandibular gland. J Oral Maxillofac Surg. 2012; 70(10):2356-9. 13. Jemal A, Siegel R, Ward E, Murray T,XuJ, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43- 66. 14. Kokenek-Unal TD, Gumuskaya B, Ocal B, Alper M. A Rare Cause of Nasal Obstruction: Metastatic Renal Cell Carcinoma. Case Reports in Pathology.2016;ID 2560749:1-3. 15. Antonelli A, Arrighi N, Corti S, Legramanti S, Zanotelli T, Cozzoli A et al. Surgical treatment of atypical metastasis from renal cell carcinoma (RCC). BJU International.2012;110(11):E559–E563.
- 16. Nason R, Carrau RL. Metastatic renal cell carcinoma to the nasal cavity, American Journal of Otolaryngology—Head and Neck MedicineandSurgery. 2004;25(1):54–7. 17. Cui P, CongX,Yin J, Liu M, LiuM,WangX,Yang L et al. Metastases to the nose from clear cell renal cell carcinoma:Acasereport.Medicine(Baltimore).2019 ;98(4):e14012. 18. Sountoulides P, Metaxa L, and Cindolo L. Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports, Journal of Medical Case Reports.2011.5:429. 19. Özen A, Kasapoğlu ED, Açıkalın MF, Can C. Berrak hücreli karsinomda Fuhrman derecesinin tekrarlanabilirliğinin ve prognostik kullanımının değerlendirmesi. Osmangazi Tıp Dergisi. 2014; 36(3), 13-20.