Sedanur KARAMAN GÜLSARAN, Volkan BAŞ, Onur KIRKIZLAR, Ahmet Muzaffer DEMİR, Gökhan ÖZTÜRK, Mehmet BAYSAL, Elif G. ÜMİT

Akut Myeloid Lösemide CD11b İfadesinin Hemostatik Komplikasyonlar ve Tedaviye Yanıt ile İlişkisi

Amaç: Çalışmamızda, Akut Myeloid Lösemi (AML) hastalarında CD11b ekspresyonunun klinik seyir ve hastalığın prognozu üzerine etkilerini araştırmayı amaçladık.Materyal ve Metot: Trakya bölgesindeki bir üçüncü basamak hastane olan Trakya Üniversitesi Tıp Fakültesi, Hematoloji Anabilim Dalı'nda2014-2017 yılları arasında, Dünya Sağlık Örgütü 2016 myeloid maligniteler sınıflamasına göre AML tanısı almış 123 hastanın verileri retrospektif olarak değerlendirildi.Bulgular: Çalışmamızdaki 123 hastanın 60'ı kadın, 63'ü erkekti. Yaş ortalaması 57.93 idi. CD11b pozitifliği 40 hastada gözlendi. CD 11b pozitifliği olan hastalarda trombosit sayısı anlamlı derecede düşüktü (p = 0.004). Aynı şekilde, D-dimer düzeyleri de CD11b pozitif hasta grubunda daha yüksekti (p = 0.000). Sonuçlar ile ilgili olarak, CD 11b pozitifliği olan hastalarda ilk remisyon indüksiyon tedavisi ile remisyon oranlarının daha düşük olduğu bulundu (p = 0.003). Kaplan Meier sağkalım analizinde; CD-11b pozitifliği ile genel sağkalım arasındabir ilişki bulunamadı (CD 11b pozitif grupta 8,5 ay, negatif grupta 12,1 ay, p: 0.436).Sonuç: Çalışmamızda CD11b ifadesi olan hastaların remisyon indüksiyon kemoterapisi ile daha düşük remisyon oranlarına sahip olduğunu saptadık.

CD11B EXPRESSION IN ACUTE MYELOID LEUKEMIA IS ASSOCIATED WITH HEMOSTATIC COMPLICATIONS AND RESPONSE TO TREATMENT

Aim: In our study, we aimed to investigate the effects of CD11b expression on myeloblasts on clinical course and prognosis in patients with AML. Materials and Methods: Data of 123 patients diagnosed with AML between 2014-2017 in Trakya University Faculty of Medicine, Department of Hematology, a tertiary referral hospital in the Trakya Region, were evaluated in a retrospective manner. The diagnosis of AML was based on WHO 2016 criteria of Myeloid Neoplasms. Results: Of the 123 patients in our study, 60 were female, and 63 were male. The mean age was 57.93 years. CD11b positivity was observed in 40 patients. Platelet counts were significantly lower in patients with CD11b positivity (p = 0.004). Likewise, D-dimer levels at presentation were higher in the CD11b positive patient group (p = 0.000). Regarding outcomes, patients with CD11b positivity were found to have lower rates of remission with first-line remission induction therapy (p = 0.003). There was no significant relationship between CD11b positivity and overall survival with Kaplan Meier survival analysis (8.5 months in CD 11b positive group, 12.1 months in negative group, p: 0.436). Conclusion: Our study demonstrated that patients with CD11b expression had lower remission rates with remission induction chemotherapy.

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