KALP BİR POMPADAN ÖTE BİR ŞEY OLAMAZ MI?

Kalp nakillerinden sonra meydana gelen kişilik değişiklikleri, kalp ve beyin arasındaki karşılıklı iletişim, REM (rapid eye movement) uykusu sırasında kardiyovasküler düzenlemede amigdalanın rolü, yine REM uykusunun gelişmekte olan beyinde nöron gelişimi ve hafıza konsolidasyonu üzerindeki etkileri, atriyal ve beyin natriüretik peptitlerin çeşitli etkileri ve kardiyak nöral krista hücrelerinin kalp gelişimindeki rollerine dayanarak bu çalışmada kalbin ve özellikle SA (sinoatriyal) düğümün emosyonel hafıza işleme ve saklamada etkin olabileceği hipotezini öne sürdüm. Bunun da ötesinde SA düğümüne yapılacak çeşitli müdahelelerin, altında istenmeyen anıların ve yaşam deneyimlerinin yattığı düşünülen bazı psikiyatrik hastalıklarda tedavi amaçlı olarak kullanılabileceği önerisi de tartışıldı.

Anahtar Kelimeler:

SA nod, kalp nakli, nörokardiyak etkilesim, duygudurum

COULDN’T HEART BE MORE THAN A PUMP?

Based on the 1) personality changes observed following heart transplantations; 2) the two-way, dynamic, ongoing dialog between the brain and the heart and its reflection as alterations in heart rate variability; 3) the prominent role of amygdala in cardiovascular regulation during rapid eye movement sleep and 4) the importance of rapid eye movement sleep in the developing brain to establish proper neuronal circuits and its memory consolidation effect; 5) the role of cardiac neural crest cells in heart development and 6) the effects of Atrial and Brain Natriuretic Peptides; I hypothesize that the heart, particularly the SA node, could function in emotional memory processing and storage in collaboration with related brain regions. Moreover, intervention to SA node in certain psychiatric diseases with underlying unwanted memories and life experiences could be a novel choice of therapy.

Keywords:

SA node, heart transplantation, neurocardiac interaction, emotion,

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