COVİD-19 Pnömonisinde Prokalsitonin Düzeylerinin Önemi

Amaç: Bu çalışmadaki amacımız, RT-PCR (Real-Time Polymerase Chain Reaction) pozitif COVID-19 pömonisinde prokalsitonin seviyelerinin nasıl etkilendiğini tespit etmek. Bu parametrenin RT-PCR pozitif hastalarda biyokimyasal parametre açısından değerini araştırmak, konuyla ilgili yeni görüşler ileri sürebilmektir. Gereç ve Yöntem: Çalışmamıza hastaneye başvuran 18 yaş üstü RT-PCR testi pozitif olup servise yatışı olan 100 COVİD-19 hasta dahil edildi. Hastaların verileri hastanenin sisteminden geriye dönük olarak toplandı. RT-PCR pozitif hastalar toraks BT (bilgisayarlı tomografi) pozitif ve BT negatif diye iki gruba ayrıldı ve bu iki grup arasında prokalsitonin değerleri araştırıldı. Elde elden sonuçlar SPSS 25 programında değerlendirildi. Bulgular: RT-PCR testi pozitif olan 100 hastanın 39'unda BT negatif, 61'inde BT pozitifti. BT pozitif hasta grubunda ölçülen prokalsitonin düzeyleri, BT negatif hasta grubuna göre yüksek olmasına rağmen istatiksel olarak anlamlı bulunmadı (0.113±0.154 ng/mL, 0.064±0.058 ng/mL, p=0.510). Sonuç: Elde ettiğimiz sonuçlar prokalsitonin düzeyinin RT-PCR pozitif hastalarda COVID-19 pnömonisinin varlığını ayırt edemeyeceğini göstermektedir. Prokalsitonin düzeyindeki yükseklik hastalığın daha komplike bir hale geldiğini öngörebilir.

Anahtar Kelimeler:

COVID-19, Pnömoni, Prokalsitonin

The Importance of Procalcitonin Levels in COVID-19 Pneumonia

Objective: Our aim in this study is to determine how procalcitonin levels are affected in RT-PCR (Real-Time Polymerase Chain Reaction) positive COVID-19 pneumonia. To investigate the value of this parameter in terms of biochemical parameters in RT-PCR positive patients and to propose new opinions on the subject. Methods: One hundred COVID-19 patients admitted to the hospital with positive RT-PCR test and above the age of 18 were included in our study. The data of the patients were collected retrospectively from the hospital system. RT-PCR positive patients were divided into two groups as thoracic CT (computed tomography) positive and CT negative, and procalcitonin values were investigated between these two groups. The obtained results were evaluated in the SPSS 25 program. Results: Of the 100 patients with positive RT-PCR tests, 39 patients were CT negative and 61 patients were CT positive. Although the procalcitonin levels measured in the CT positive patient group were higher than the CT negative group, it was not statistically significant (0.113 ± 0.154 ng / mL, 0.064 ± 0.058 ng / mL, p = 0.510). Conclusion: Our results show that the procalcitonin level cannot distinguish the presence of COVID-19 pneumonia in RT-PCR positive patients. High procalcitonin levels may predict that the disease becomes more complicated.

Keywords:

COVID-19, Pneumonia, Procalcitonin,

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