COVID-19 hastalarında çinko düzeylerinin incelenmesi

Amaç: Çinko (Zn), immün yanıtı güçlendirici etkisinin yanı sıra viral enfeksiyonlara karşı savunmada da rol oynadığı bilinen önemli bir eser elementtir. Bu çalışma ile kliniğimizde izlenen COVID-19 olgularında Zn düzeylerinin belirlenerek, rutin laboratuvar parametreleri ve hastalık şiddeti ile olan ilişkisinin irdelenmesi amaçlanmıştır. Yöntem: Çalışmaya 135 COVID-19 hastası ile 26 sağlıklı birey dahil edilmiştir. Serum Zn, düzeyleri kolorimetrik yöntem ile ölçülmüştür. Ayrıca kreatinin, ALT, AST CK, LDH, ferritin, CRP, D-dimer ve fibrinojen düzeyleri değerlendirilmiştir. Bulgular: Serum Zn düzeyleri tüm hasta gruplarında kontrol grubuna kıyasla; orta, ağır ve kritik hasta gruplarında ise hafif hasta grubuna kıyasla istatistiksel olarak anlamlı düzeyde düşük bulunmuştur. Ayrıca Zn düzeyleri kreatinin, ALT, AST, CK, lökosit düzeyleri ile zayıf negatif ve anlamlı bir korelasyon gösterirken, yaş, CRP, ferritin, D-dimer ve fibrinojen düzeyleri ile anlamlı, orta derecede ve negatif yönde bir korelasyon göstermiştir. Sonuç: Serum Zn düzeyleri COVID-19 hastalarında sağlıklı bireylere göre istatistiksel olarak anlamlı oranda daha düşüktür. COVID-19 olgularında hastalık şiddeti ile serum Zn düzeyleri arasında net bir ilişki bulunamamış olsa da hastalık şiddeti ile ilişkili biyokimyasal ve inflamatuar markırlar ile serum Zn düzeyleri arasında anlamlı bir ilişki olduğu görülmüştür.

Anahtar Kelimeler:

Koronavirüs Hastalığı, Çinko, İnflamasyon

Investigation of zinc levels in patients with COVID-19

Objective: Zinc (Zn) is an important trace element known to play a role in defense against viral infections as well as its immune response enhancing effect. In this study, it was aimed to determine Zn levels in COVID-19 cases followed in our clinic and to examine its relationship with routine laboratory parameters and disease severity. Method: One hundred thirty-five COVID-19 patients and 26 healthy individuals were included in the study. Serum Zn levels were measured by colorimetric method. In addition, creatinine, ALT, AST CK, LDH, ferritin, CRP, D-dimer and fibrinogen levels were evaluated. Results: Serum Zn levels in all patient groups compared to the control group; it was found to be statistically significantly lower in the moderate, severe and critical patient groups compared to the mild patient group. In addition, while Zn levels showed a weak negative and significant correlation with creatinine, ALT, AST, CK, leukocyte levels, they showed a significant, moderate and negative correlation with age, CRP, ferritin, D-dimer and fibrinogen levels. Conclusion: Serum Zn levels are statistically significantly lower in COVID-19 patients than in healthy individuals. Although there was no clear relationship between the severity of the disease and serum Zn levels in COVID-19 cases, it was observed that there was a significant relationship between the biochemical and inflammatory markers associated with the severity of the disease and serum Zn levels.

Keywords:

Zinc, Coronavirus Disease, İnflammation,

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