The basic principle of this study, a single particle bring together more than one material, it developed a variety of physical, chemical and biological properties to design particle systems show. Where in the core-shell particles were synthesized in four steps: In the first stage metal (Ag, Au,) particles were produced using plant bioextracts. In a second stage, SiO2 microspheres were prepared according to Stboer process.In the third stage, surface of silica  was modifiedIn the final stage, the metal particles (Au, Ag) were immobilized   to the silica surface.