Objective: In this study, positivity of Helicobacter pylori which is very common health problem for human, was examined by C 14 urine breath test and in this group also blood samples, acute phase reactants, tumor markers were examined for the specific correlationMethods: Blood samples of 130 patients which was examined by C 14 urine breath test, were drawn. In order to perform the urea breath test, which was the basis of our study, the patient was starved for at least 6 hours before the test and did not use antibiotics 1 month before and active acid inhibitors 1 week before. Following a 6-hour hunger period, 37 kBg of 14 C-urea capsules 50 mL water were given. Breath samples were collected at 10 minutes with a dry cartridge system (BREATHCARD).  In this group also blood samples, acute phase reactants (crp, aso, sedim, rf), tumor markers (CEA, CA 19-9, CA 15-3) were examined for the specific correlation. Results: Test results for 57 of 130 patients were found to be positive (43.84%) while it was found to be negative (56.16%) in 73 patients. Reference ranges for blood parameters were 13.6-17.2 for HGB, 39.5-50.3 for HCT, 5.2-12.4 for WBC, 0-200 for ASO, 3.02 for CRP, 0-15 for RF, 0-3 for CEA, 0-35 for CA 19-9, 0-31.3 for CA 15-3 The mean age of patients with negative H. pylori infection was 39.41 and the positive was 39.03. 35 of the 57 H. pylori positive patients in the total 130 patients were female (61.4%), 22 were male (38.6%); Of 73 negative patients, 44 were female (60.3%) and 29 were male (39.7%). There was no sex-related collagen of H. pylori. 22 persons (38.6%) of the positive H. pylori blood group were found in the blood group A, 9 (15.8%) were in the blood group B, 11 (19.3%) were in the group AB and 15 (26.3%) were in the group O. It was observed that 21 patients (28.8%) in negatives of H. pylori were blood group A, 17 patients (23.3%) were blood group B, 14 patients (19.2%) were blood group AB and 21 patients (28.8%) were group O.  No significant difference was observed between blood groups and H. pylori infection with Rh factor, and no linkage was detected. Conclusion: As a result, there were no significant correlation were found between acute phase reactants, tumor markers and ABO/ Rh blood groups for H. pylori positives.