Relationship Between BCL-2 and Ki-67 in Chronic Sialadenitis
Relationship Between BCL-2 and Ki-67 in Chronic Sialadenitis
Objective: Apoptosis or programmed cell death can be triggered by a variety of physiological and pathological signals. B-cell lymphoma-2 (Bcl-2) is an important anti-apoptotic protein of apoptosis pathways, mainly localized in intracellular membranes in mitochondrial outer membrane nuclear membrane and endoplasmic reticulum. BCL-2 family molecules can be stocked by upstream with irreversible cellular damage sites and have an important role in apoptosis studies. The best known antibody for identifying proliferating cells is Ki-67. There is a clear correlation between Ki-67 and the number of mitoses. Ki-67 is a nuclear protein that is believed to play a role in the early stages of rRNA synthesis ex- pressed in the G1, S, G2 and M phases except for the G0 phase of the cell cycle. In this study, we evaluated the expression of BCL-2 and Ki-67 in the pathogenesis of chronic sialadenitis.Methods: This study was included 18 cases of chronic sialadenitis. The immunohistochemistry BCL-2 and Ki-67 antibodies was performed in cases.Results: Statistically, there were significant correlation between BCL-2 and Ki-67 expression in acinar cells (p= 0.016). There was significant correlation between BCL-2 and Ki-67 expression in ductus and epimyoepithelial islands (p= 0.017). There was significant correlation between ductal and acinar cells on account of Ki-67 expression (p= 0.010). Conclusion: In this study, it was seen that decrease of BCL-2 and Ki-67 expression in acinar cells was higher than ductal epithelial cells.
Keywords:
BCL-2 Ki-67, chronic sialadenitis,
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- 1. Nagata S, Golstein P. The Fasdeathfactor. Science.1995; 267:1449 –1456.
- 2. Cohen JJ: Programmed cell death in the immune system. AdvImmunol. 1991; 50: 55-58.
- 3. Wilson KF, Meier JD, Ward PD. Salivary gland disorders. Am Fam Physician. 2014;89(11):882-8.
- 4. Tarpley, T. M.,Jr, Anderson, L. G. and White, C. L. Minor salivary gland involvement in Sjogren’s syndrome. Oral Surg. Oral Med. Oral Pathol.1974;.37:64.
- 5. Carracedo, G.,Peral, A. And Pintor, J. Diadenosine polyphosphates in tears of Sjogren syndrome patients. Invest Ophthalmol. Vis. Sci. 2010;51:5452.
- 6. Sisto, M., Lisi, S., Lofrumento, D., D’Amore, M., Scagliusi, P. AndMitolo, V. Autoantibodies from Sjogren’s syndrome trigger apoptosis in salivary gland cell line. Ann. N. Y. Acad. Sci. 2007;1108:418.
- 7. Ramos-Casals, M. and Font, J. Primary Sjogren’s syndrome: current and emergentaetiopathogenic concepts. Rheumatology (Oxford) 2005;44:1354.
- 8. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 1984; 226(4678):1097-1099.
- 9. Sasi N, Hwang M, Jaboin J, Csiki I, Lu B: Regulated cell death pathways: new twists in modulation of BCL2 family function. Mol Cancer Ther 2009; 8(6):1421-1429.
- 10. Cotter TG: Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer 2009; 9(7):501-507.
- 11. Certo M, Del GaizoMoore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, et al: Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 2006; 9(5):351-365.
- 12. H.H. Xia, G.S. Zhang, N.J. Talley, B.C. Wong, Y. Yang, C. Henwood, J.M. Wyatt, S. Adams, K. Cheung, B. Xia, Y.Q. Zhu, S.K. Lam Am. J. Gastroenterol. 2002; 97 (12), pp. 3023–3031.
- 13. Şule Bulut, Hilal Uslu, B Handan Özdemir, Ömer Engin Bulut. Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis. Head&Face Medicine 2006;2:17.
- 14. MT Abou Elkhier, RR EL-Zehary, MI Mourad, NT Abou El-Khier. Immunohistochemical assessment of Bcl-2 and Ki-67 in gingival tissues of normal and immunosuppressed patients as predictors of neoplasia. Annals of Oral & Maxillofacial Surgery 2014 Jul 10;2(2):14.
- 15. Ogasawara, Takefumi, et al. "Sclerosing polycystic adenosis with intraluminal crystalloids of the buccal mucosa: A case report and review of the literature." Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 27.4 (2015): 580-587.
- 16. Bascones A, Gamanol J, Gomez M, Silva A, Gonzalez MA: New knowledge of the pathogenesis of periodonta disease. QuintessenceInt2004;35:706-716.
- 17. Senturk N, Yildiz L, Sullu Y, Kandemir B, TuranliAY.Expression of bcl-2 protein in active skin lesion of Behçet’s disease Int J Dermatol. 2001;40(12):747-50.
- 18. Wang YH, Yan Y, Rice JS, Volpe BT, Diamond B.Enforced expression of the apoptosis inhibitor bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanism J Autoimmun. 2011;37(1):18-27.
- 19. Arreaza AJ, Rivera H, Correnti M. Expressionof COX-2 and bcl-2 in oral lichen planus lesions and lichenoid reactions. Ecancermedical science. 2014;8:411.
- 20. Qi G, Hua H, Gao Y, Lin Q, Yu GY. Sialoadenitis progression in nonobese diabetic mice and its correlation with expression of apoptosis-associated proteins in salivary glands and serum IgG levels. . Chin Med J (Engl). 2007;120(16):1426-31.
- 21. Polihronis M,Tapinos NI, Theocharis SE, Economou A, Kittas C, Moutsopoulos HM. Modes of epithelial cell death and repair in Sjögren's syndrome (SS). ClinExpImmunol 1998; 114:485–490.
- 22. Robert E. Gerstenbluth, Allen D. Seftel Gregory T. Mac Lennan, R. NagarjunRao, Eric W.Corty, Kelly Ferguson, Martin I. Resnick. Distribution of Chronic Prostatitis in Radical Prostatectomy Specimens With Up-Regulation of BCL-2 in Areas of Inflammation .J Urol. 2002;167(5):2267-70.
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 2015
- Yayıncı: Ordu Üniversitesi
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Relationship Between BCL-2 and Ki-67 in Chronic Sialadenitis