Obezite ve Nesfatin-1 İlişkisi: Bir Meta Analiz Çalışması

Amaç: Nesfatin-1, anoreksijenik etkiye sahip tokluk peptidi olarak tanımlanan yeni bir peptittir. Çalışmalar nesfatin-1’in birçok fizyolojik faaliyetin gerçekleştirilmesinde görev aldığını göstermektedir. Öte yandan, nesfatin-1’in diyabet ve nörojenik hastalıkların yanı sıra obezite de rol oynadığı birçok çalışmada vurgulanmaktadır. Çalışmamızda, obez bireylerdeki plazma nesfatin-1 seviyelerinin obez olmayan gruplara göre anlamlı bir farka sahip olup olmadığını meta analiz ile araştırmayı amaçladık. Yöntem: Çalışmada, obez ve obez olmayan bireylerdeki plazma nesfatin-1 seviyelerini gösteren 11 çalışma (12 bulgu) değerlendirilmiştir. Tüm yaş gruplarına sahip çalışmalar ile yetişkin ve çocuk gruplarında meta analiz yapılmıştır. Rasgele etki modeli kullanılarak genel etki büyüklüğü hesaplanmıştır. p<0.05 istatistiksel olarak anlamlı kabul edilmiştir. Bulgular: Meta analiz sonuçları, tüm yaş grupları bir arada değerlendirildiğinde nesfatin-1 seviyelerinin obez gruplarda obez olmayan gruplara göre anlamlı bir azalmaya sahip olduğunu göstermektedir (p<0.05). Yetişkin ve çocuk gruplarının da meta analiz ile ayrı ayrı değerlendirilmesi sonucunda, yine obez bireylerin obez olmayan gruplara göre plazma nesfatin-1 seviyelerinin anlamlı olarak azaldığı ortaya çıkmaktadır (p<0.05). Sonuç: Sonuç olarak, meta analiz sonuçlarımız nesfatin-1’in yaştan bağımsız olarak sentez ve salınımının vücut ağırlık artışına bağlı değişim gösterebileceğine işaret etmektedir.

Anahtar Kelimeler:

Nesfatin-1, obezite, meta-analiz

The Relationship between Obesity and Nesfatin-1: A Meta-Analysis Study

Aim: Nesfatin-1 is a new peptide defined as a satiety peptide with anorexigenic effect. Studies show that nesfatin-1 is involved in the realization of many physiological activities. On the other hand, it is emphasized in many studies that nesfatin-1 plays a role in obesity as well as diabetes and neurogenic diseases. In our study, we aimed to investigate whether plasma nesfatin-1 levels in obese individuals had a significant difference compared to non-obese groups with a meta-analysis. Method: In the study, 11 studies (12 findings) showing plasma nesfatin-1 levels in obese and non-obese individuals were evaluated. Meta-analysis were conducted in studies with all age groups and in adult and child groups. The overall effect size was calculated using the random effect model. p<0.05 was considered statistically significant. Results: Meta-analysis results showed that when all age groups were evaluated together, nesfatin-1 levels were significantly lower in obese groups than non-obese groups (p<0.05). The separate evaluation of the adult and child groups with the meta-analysis revealed that the plasma nesfatin-1 levels of obese individuals were significantly lower than the non-obese groups (p<0.05). Conclusion: In conclusion, our meta-analysis results indicated that the synthesis and release of nesfatin-1 may vary depending on body weight gain, regardless of age.

Keywords:

Nesfatin-1, obesity, meta-analysis,

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