The Relationship between Vitamin D and Quality of Life in Patients with Fibromyalgia Syndrome

Fibromyalgia, is a widespread chronic pain syndrome accompanied by tiredness, depression and sleep disorders. The etiology and pathogenesis have not yet been fully clarified. As the pain is accompanied by tiredness, sleep disorders and psychiatric symptoms, daily activities and quality of life can be affected. Muscle weakness due to reduced vitamin D synthesis causes an increase in pain in the musculoskeletal system, in impaired balance and in the number of falls. Quality of life is negatively affected by these problems. Previous studies have shown that a reduction in vitamin D levels is common in fibromyalgia syndrome. The aim of this review was to provide an overall view of the relationship between vitamin D and quality of life in patients with fibromyalgia syndrome.

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1. Bellato E, Marini E, Castoldi F, Barbasetti N, Mattei L, Bonasia DE, Blonna D. Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment. Pain Res Treat. 2012;2012:426130.

2. Clauw DJ. Fibromyalgia: an overview. Am J Med. 2009;122(Suppl 12):3-13.

3. Mease P. Fibromyalgia syndrome: Review of clinical presentation, pathogenesis, outcome measures and treatment. J Rheumatol Suppl. 2005;32(Suppl 75):6-21.

4. Gervin RD. A review of myofacial pain and fibromyalgia factors that promotic their persistence. Acupuncture Med. 2005;23(3):121-34.

5. Pagano T, Matsutani LA, Ferreira EA, Marques AP, Pereira CA. Assessment of anxiety and quality of life in fibromyalgia patients. Sao Paulo Med J. 2004;122(6):252-8.

6. Gervin RD. Myofacial and visceral pain syndromes: visceral and somatic pain representations. J Musculoskeletal Pain 2002;10(1-2):165-75.

7. Al Allaf AW, Mole PA, Paterson CR, Pullar T. Bone health in patients with fibromyalgia. Rheumatology. 2003;42(10):1202-6.

8. Price DD, Staud R. Neurobiology of fibromyalgia syndrome. J Rheumatol Suppl. 2005;32(Suppl 75):22-8.

9. Abeles AM, Pillinger MH, Solitar BM, Abeles M. Narrative review: the pathophysiology of fibromyalgia. Annals of Internal Medicine. 2007;146(10):726-34.

10. McBeth J, Silman AJ. The role of psychiatric disorders in fibromyalgia. Current Rheumatology Reports. 2001;3(2):157-64.

11. Zanni GR. Diagnosing and treating fibromyalgia. Consult Pharm. 2009;24(8):572-8.

12. The World Health Organization Quality of Life Assessment (WHOQOL): position paper from the World Health Organization. Soc Sci Med. 1995;41(10):1403-9.

13. Campos R, Vázquez M. Health-related quality of life in women with fibromyalgia: clinical and psychological factors associated. Clin Rheumatol. 2012;31(2):347-55.

14. Homann D, Stefanello JM, Goes SM, Breda CA, Paiva Edos S, Leite N. Stress perception and depressive symptoms: functionality and impact on the quality of life of women with fibromyalgia. Rev Bras Reumatol. 2012;52(3):319-30.

15. Göksoy T. Osteoporozda Tanı ve Tedavi. Özlem Grafik Matbaacılık, İstanbul, 2000. 16. Mosekilde L. Vitamin D and the elderly. Clin Endocrinol. 2005;62(3):265-81.

17. Dhesi JK, Jackson SH, Bearne LM, Moniz C, Hurley MV, Swift CG, Allain TJ. Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing. 2004;33(6):589-95.

18. Zamboni M, Zoico E, Tosoni P, Zivelonghi A, Bortolani A, Maggi S, Di Francesco V, Bosello O. Relation between vitamin D, physical performance, and disability in elderly persons. J Gerontol A Biol Sci Med Sci. 2002;57(1):M7-11.

19. Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculo-skeletal pain. Mayo Clin Proc. 2003;78(12):1463-70. 20. Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J, Charles P, Eriksen EF. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med. 2000;247(2):260-8.

21. McGrath J. Hypothesis: is low prenatal vitamin D a risk-modifying factor for schizophrenia? Schizophr Res. 1999;40(3):173-7.

22. Berne RM, Levy MN, Koeppen BM, Stanton BA. Physiology 5th edition. Mosby, 2003. 23. Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005;10(2):94-111.

24. Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25-dihydroxy vitamin D3 and the immune system. Am J Clin Nutr. 2004;80(Supp 6):1717S-20S.

25. Cantorna MT, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood). 2004;229(11): 1136-42.

26. McKenna MJ. Differences in vitamin D status between countries inyoung adults and elderly. Am J Med. 1992;93(1):69-77.

27. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81(3):353-73.

28. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of otimal serum concentrations of 25-hydroxy vitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28.

29. Calvo MS, Whiting SJ. Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use. Nutr Rev. 2003;61(3):107-13.

30. Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998;338(12):777-83.

31. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998;351(9105):805-6.

32. Holick MF. Vitamin D Deficiency: What a Pain It Is. Mayo Clin Proc. 2003;78(12):1457- 9. 33. Bhatty SA, Shaikh NA, Irfan M, Kashif SM, Vaswani AS, Sumbhai A, Gunpat J.

Vitamin D deficiency in fibromyalgia. J Pak Med Assoc. 2010;60(11):949-51. 34. Holick MF, Chen TC. Vitamin D deficiency: a word-wide problem with health concequences. Am J Clin Nutr. 2008;87(4):1080S-6S.

35. Iqbal R, Khan AH. Possible causses of vitamin D deficiency (VDD) in Pakistani population residing in Pakistan. J Pak Med Assoc. 2010;60(1):1-2.

36. Haddad JG. Vitamin D-Solar rays, the milky way or both? N Engl J Med. 1992;326(18):1213-5. 37. Shihadeh Y. Güneşe maruz kalma şekillerinin D vitamini üretimindeki rolü. İstanbul Üniversitesi İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Uzmanlık Tezi. İstanbul, 1998.

38. Turner MK, Hooten WM, Schmidt JE, Kerkvliet JL, Townsend CO, Bruce BK. Prevalence and clinical correlates of vitamin D inadequency among patients with chronic pain. Pain Med. 2008;9(8):979-84.

39. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.

40. Marwaha RK, Tandon N, Reddy DR, Aggarwal R, Singh R, Sawhney RC, Saluja B, Ganie MA, Singh S. Vitamin D and bone mineral density status of healthy school children in northern India. Am J Clin Nutr. 2005;82(2):477-82.

41. Sedrani SH. Low 25-hydroxy vitamin D and normal serum calcium concentrations in Saudi Arabia: Riyadh region. Ann Nutr Metab. 1984;28(3):181-5.

42. Holick MF. Too little vitamin D in premenopausal women: why should we care? Am J Clin Nutr. 2002;76(1):3-4.

43. Huisman AM, White KP, Algra A, Harth M, Vieth R, Jacobs JW, Bijlsma JW, Bell AD. Vitamin D Levels in Women with Systemic Lupus Erythematosus and Fibromyalgia. J Rheumatol. 2001;28(11):2535-9.

44. Abokrysha NT. Vitamin D deficiency in women with fibromyalgia in Saudi Arabia. Pain Med. 2012;13(3):452-8.

45. Tandeter H, Grynbaum M, Zuili I, Shany S. Serum 25-OH vitamin D levels in patients with fibromyalgia. Isr Med Assoc J. 2009;11(6):371-2.

46. Okumus M, Koybası M, Tuncay F, Ceceli E, Ayhan F, Yorgancioglu R, Borman P. Fibromyalgia syndrome: is it related to vitamin D deficiency in premenopausal female patients? Pain Manag Nurs. 2013;14(4):e156-63.