Ayşe ÖZDEMİR, Utku Dönem DİLLİ, Salim NESELİOGLU, Özcan EREL

The relationship between thiol-disulfide balance and prostate cancer

This study aimed to investigatethe possible association of thiol/disulfidehomeostasiswith prostate-specific antigen levelsin prostate cancer patients and to compare the results with a normal healthy population ofa similar age group for the first time in literature. Forty-twopatients (20 patientswith prostate cancer and 22 volunteers) were included in the study. Thiol/disulfide homeostasis tests were measured with an automated method. Albumin, carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), ischemia modified albumin (IMA), total thiol (TT), native thiol (–SH), and disulfide (–S–S–) levelsand, thiol-disulfide ratios (disulfide / native thiol, disulfide/total thiol and native thiol/total thiol) were assessed to detect any differences between prostate cancer group and control group. The mean PSA value of the prostate cancer group was 2.56 ng/mL, the mean PSA value of the control group was 1.21 ng/mL, and the mean age of the prostate cancer group was 67.32 years, the mean age of control group was 60.09. Although native thiol and total thiol levels were significantly lower in patients with prostate cancer (p 0.05). In our study, we could not show thiol-disulfide values as a biochemical prognostic factor in patients with prostate cancer. We believe that serum TT, –SH, –S–S– concentrations cannot serve as a noninvasive biomarker for prostate cancer. To verify the biochemical role of thiol/disulfide balance, studies need to be done by increasing the number of patients with prostate cancer.

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