Kübra ÖZKÖK KANGAL, Taylan ZAMAN, Cesur ÜSTÜNEL

The outcomes of hyperbaric oxygen therapy in patients with sudden hearing loss and analysis of the treatment outcome prediction value of early treatment response possible

Sudden hearing loss (SHL) is an otologic emergency. This study aimed to evaluate the outcomes of hyperbaric oxygen therapy (HBOT) in patients with SHL. Secondly, we aimed to assess whether early treatment response (ETR) of HBOT at the end of the 5th (5ETR) and 10th sessions (10ETR) could predict overall HBOT outcomes. Patients' files who underwent HBOT due to SHL between 01.01.2017 - 31.12.2018 were retrospectively analyzed. Patients without an audiogram before HBOT and who did not meet the SHL definition, who were under 18 years old were excluded. Demographic data, delay time to HBOT, the severity of SHL, etiology, steroid administrations, number of HBOT sessions, and audiograms were analyzed. A total of 51 patients were included. The mean number of HBOT sessions was 17.6±5.9. There was a statistically significant improvement in each frequency and pure tone average (PTA) at the end of HBOT (p

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1. Wilson WR, Byl FM, Laird N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol. 1980;106:772–76.
2. Chandrasekhar SS, Tsai Do BS, Schwartz SR, et al. Clinical practice guideline: sudden hearing loss (Update). Otolaryngol Head Neck Surg. 2019;161(1_suppl):1-45.
3. Mattox DE, Simmons FB. Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol. 1977;86:463–80.
4. Stokroos RJ, Albers FWJ. The etiology of idiopathic sudden sensorineural hearing loss: a review of the literature. Acta Otorhinolaryngol Belg. 1996;50:69–76.
5. Agarwal L, Pothier DD. Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev 2009:CD003422.
6. Aslan I, Oysu C, Veyseller B, Baserer N. Does the addition of hyperbaric oxygen therapy to the conventional treatment modalities influence the outcome of sudden deafness? Otolaryngol Head Neck Surg 2002;126:121–6
7. Topuz E, Yigit O, Cinar O, Seven H. Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss? Eur Arch Otorhinolaryngol 2004;261:393–6.
8. Narozny W, Kuczkowski J, Kot J, et al. Prognostic factors in sudden sensorineural hearing loss: our experience and a review of the literature. Ann Otol Rhinol Laryngol 2006;115:553–8.
9. Alimoglu Y, Inci E, Edizer DT, et al. Efficacy comparison of oral steroid, intratympanic steroid, hyperbaric oxygen and oral steroid and hyperbaric oxygen treatments in idiopathic sudden sensorineural hearing loss cases. Eur Arch Otorhinolaryngol. 2011;268:1735-41.
10. Liu SC, Kang BH, Lee JC, et al. Comparison of therapeutic results in sudden sensorineural hearing loss with / without additional hyperbaric oxygen therapy: a retrospective review of 465 audiologically controlled cases. Clin Otolyarngol. 2011;36:121-8.
11. Fujimura T, Suzuki H, Shiomori T, et al. Hyperbaric oxygen and steroid therapy for idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol. 2007;264:861-6.
12. Cavallazzi GM. Relations between O2 and hearing function. Eds: Marroni A, Oriani G, Wattel F. Proceedings of International Joint Meeting on Hyperbaric and Underwater Medicine, 4-8 September 1996. Milano, Italy, p 633–45.
13. Nagahara K, Fisch U, Yagi N. Perilymph oxygenation in sudden and progressive sensorineural hearing loss. Acta Otolaryngol. 1983;96:57-68. 14. Lamm C, Walliser U, Schumann K, Lamm K. Oxygen partial pressure measurements in the perilymph and the scala tympani in normo- and hyperbaric conditions. An animal experiment study. HNO. 1988;36:363–6.
15. Feldmeier, John J. Hyperbaric oxygen 2003: indications and results: the hyperbaric oxygen therapy committee report. Undersea and Hyperbaric Medical Society, 2003.
16. Bayoumy AB, de Ru JA. The use of hyperbaric oxygen therapy in acute hearing loss: a narrative review. Eur Arch Otorhinolaryngol. 2019;276:1859- 80.
17. Desloovere C, Germoupre P. Sudden sensorineural deafness: treatment with hyperbaric oxygen therapy after failure of ten-day course of "classical" drug therapy. In Proceedings of the 23rd EUBS Congress, European Underwater and Baromedical Society, 22-26 September 1997. Bled, Slovenia, 198–202.
18. Welslau W, Almeling M, Lammerding A, et al. How many HBO treatment are necessary for the therapy of sudden deafness and acute tinnitus? In Proceedings of the 23rd EUBS Congress, European Underwater and Baromedical Society, 22-26 September 1997. Bled, Slovenia, 203–9.
19. Schwab B, Flunkert C, Heermann R, Lenarz T. HBO in the therapy of cochlear dysfunction: first results of a randomized study. In Proceedings of the 24th EUBS Congress. European Underwater and Baromedical Society, 12-16 August 1998. Stockholm, Sweden, 40–2.
20. Korpinar S, Alkan Z, Yigit O, et al. Factors influencing the outcome of idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy. Eur Arch Otorhinolaryngol. 2011;268:41-7.
21. Karatop-Cesur I, Uzun G, Ozgok-Kangal K, et al. Early treatment response predicts outcome in patients with idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy. Undersea Hyperb Med. 2016;43:781-6.
22. Murphy-Lavoie H, Piper S, Moon RE, Legros T. Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss. Undersea Hyperb Med. 2012;39:777-92.
23. Karatop-Cesur I, Uzun G. Factors associated with treatment outcome in patients treated with hyperbaric oxygen therapy for sudden hearing loss. Master Thesis, Gulhane Military Medicine Faculty, Ankara, 2015.
24. Arslan A. Evaluation of The Timing of The Use of Hyperbaric Oxygen Therapy and Prognostic Factors in Sudden Hearing Loss. Selcuk Med J. 2020;36:232-7.
25. Yildirim E, Murat Ozcan K, Palali M, et al. Prognostic effect of hyperbaric oxygen therapy starting time for sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol. 2015;272:23-8.
26. Capuano L, Cavalıere M, Parente G, et al. Hyperbaric oxygen for idiopathic sudden hearing loss: is the routine application helpful? Acta Oto- Laryngologica 2015;135:692-7.
27. Suzuki H, Mori T, Hashida K, et al. Prediction model for hearing outcome in patients with idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol. 2011;268:497-500.
28. Ohno K, Noguchi Y, Kawashima Y, et al. Secondary hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss in the subacute and chronic phases. J Med Dent Sci. 2010;57:127-32.
29. Liu Y, Sun D, Shao S, et al. The effect of hyperbaric oxygen therapy to different degree of hearing loss and types of threshold curve in sudden deafness patients. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;24:890-4.
30. Baulieu EE, Mester J. Steroid hormone receptors. In DeGroot LJ, ed. Endocrinology. Philadelphia: W.B. Saunders Co. 1989;16–39.
31. Naiboğllu B, Külekçi S, Sürmeli M, et al. Efficacy of multimodality approach to sudden hearing loss. The Turkish Journal of Ear Nose and Throat. 2015;25:77-81.
32. Filipo R, Attanasio G, Viccaro M, et al. Hyperbaric oxygen therapy with short duration intratympanic steroid therapy for sudden hearing loss Acta Otolaryngol. 2012;132:475-81.
33. Suzuki H, Fujimura T, Shiomori T, et al. Prostaglandin E1 versus steroid in combination with hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss. Auris Nasus Larynx. 2008;35:192-7.
34. Murakawa T, Kosaka M, Mori Y, et al. Treatment of 522 patients with sudden deafness performed oxygenation at high pressure. Nihon Jibiinkoka Gakkai Kaiho. 2000;103:506-15.