Oğuzhan OKÇU, Mikail UYAN, Bayram ŞEN, Medeni ARPA

The effect of high serum lipid level on benign gallbladder diseases

There is a positive correlation between serum lipid levels and benign gallbladder diseases. We wanted to evaluate whether there is a relationship between the preoperative lipid profiles results with the presence of cholesterolosis, cholesterol polyps and cholelithiasis in the pathological examination. Patients who presented with various symptoms and underwent cholecystectomy surgery in a tertiary university hospital were retrospectively analyzed. Pathological examination records of 331 patients who had undergone cholecystectomy between 2016 and 2020 were obtained retrospectively. The latest lipid profiles results before the cholecystectomy were recorded. Patients were divided into groups according to their lipid profiles periods before cholecystectomy. The cholecystectomy reports of the patients were examined in terms of cholesterolosis, cholesterol polyp, and cholelithiasis. There was no difference between lipid profiles and the pathological subtypes in the patients whose lipid profiles were measured between 0-30 days and 0-90 days preoperatively. There was a significant difference in triglyceride levels between patients with cholesterol polyps and those without polyps, whose lipid profiles were measured within 90-180 days before surgery (p=0.031). There were significant differences in total cholesterol, triglyceride, LDL, and non-HDL levels between patients with and without cholesterolosis (p=0.017, p=0.037, p=0.048, p=0.019, respectively). There was a significant difference in triglyceride levels between patients with cholesterol polyps and those without polyps, whose lipid profiles were was measured within 0-180 days before surgery (p=0.023). There was a significant difference in total cholesterol, LDL, and non-HDL levels between patients with and without cholesterolosis (p=0.017, p=0.021, p=0.03, respectively). There is a positive correlation between preoperative serum lipid profiles and benign gallbladder diseases. The incidence of cholesterolosis and cholesterol polyps may increase after long-term exposure to high lipid concentrations.

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