Restoration of photoreceptor layer and its prognostic value in eyes with macular edema due to branch retinal vein occlusion

To evaluate the restoration of outer segment ellipsoid zone (EZ) layer and its prognostic value in visual gain following resolution of macular edema (ME) due to branch retinal vein occlusion (BRVO). In this retrospective study,33 eyes of 33 patients with ME due to BRVO who underwent intravitreal ranibizumab (IVR) injections were studied. All of the patients had the resolution of macular edema after IVR therapy. At baseline and final visit, SD-OCT scans were obtained. Best-corrected visual acuity (BCVA), central macular thickness (CMT) and integrity of outer segment ellipsoid zone (EZ) defects were determined. We divided the eyes with initial EZ defects into two groups. Group-1 had restoration of EZ and group-2 had EZ defects before and after treatment. 14 of 33 eyes (42.4%) did not have EZ defects and 19 of 33 eyes had EZ defects before treatment. 9 eyes (27.3%) had restoration of EZ defects and 2 patients (6.1%) had EZ defects after treatment while they did not have at initial visit. According to EZ change status (group-1 and group-2) the groups were similar in terms of initial BCVA and CMT. Group-1 had better final BCVA (p=0.005). There was a statically significant difference in BCVA improvement between groups (p=0.001). Disorganization of photoreceptors can have recovery after resolution of ME with ranibizumab treatment and to have better BCVA after resolution of ME, restoration of the structure of the photoreceptors is required.

___

Jefferies P, Clemett R, Day T. An anatomical study of retinal arteriovenous crossings and their role in the pathogenesis of retinal branch vein occlusions. Aust N Z J Ophthalmol. 1993;21:213-7.

Jaulim A, Ahmed B, Chatziralli IP. Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature. Retina. 2013;33:901-10.

Son BK, Kwak HW, Kim ES, et al. Comparison of ranibizumab and bevacizumab for macular edema associated with branch retinal vein occlusion. Korean J Ophthalmol. 2017;31:209-16.

Hayreh SS, Podhajsky PA, Zimmerman MB. Branch retinal artery occlusion: natural history of visual outcome. Ophthalmology. 2009;116:1188–94.

Hayreh SS. Ocular vascular occlusive disorders: natural history of visual outcome. Prog Retin Eye Res. 2014;41:1–25.

Rogers SL, McIntosh RL, Lim L, et al. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2010;117:1094–101.

Wong TY, Scott IU. Clinical practice. Retinal-vein occlusion. N Engl J Med. 2010;363:2135–44.

Mylonas G, Sacu S, Dunavoelgyi R. Response of retinal sensivity to ranibizumab treatmant of macular edema after acute branch retinal vein occlusion. Retina. 2013;33.6:1220-6.

Korobelnik JF, Kodjikian L, Delcourt C, et al. Two-year,prospective,multicenter study of the use of dexamethasone intravitreal implant for treatment of macular edema secondary to retinal vein occlusion in the clinical setting in France. Graefes Arch Clin Exp Ophthalmol. 2016;254:2307-18.

Wong IY, Iu LP, Koizumi H, et al. The inner segment/outer segment junction: what have we learnt so far? Curr Opin Ophthalmol. 2012;23:210-8.

Ota M, Tsujikawa A, Murakami T, et al. Foveal photoreceptor layer in eyes with persistent cystoid macular edema associated with branch retinal vein occlusion. Am J Ophthalmol. 2018;145:273-80.

Murakami T, Tsujikawa A, Ohta M, et al. Photoreceptor status after resolved macular edema in branch retinal vein occlusion treated with tissue plasminogen activator. Am J Ophthalmol. 2007;143:171-3.

Eandi CM, Chung JE, Cardillo-Piccolino F, et al. Optical coherence tomography in unilateral resolved central serous chorioretinopathy. Retina. 2005;25:417-21.

Piccolino FC, de la Longrais RR, Ravera G, et al. The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy. Am J Ophthalmol. 2005;139:87-99.

Sandberg MA, Brockhurst RJ, Gaudio AR, et al. The association between visual acuity and central retinal thickness in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2005;46:3349-54.

Maheshwary AS, Oster SF, Yuson RM, et al. The association between percent disruption of the photoreceptor inner segment–outer segment junction and visual acuity in diabetic macular edema. Am J Ophthalmol. 2010;150:63-7.

Sakamoto A, Nishijima K, Kita M, et al. Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy. Graefes Arch Clin Exp Ophthalmol. 2009;247:1325-30.

Otani T, Yamaguchi Y, Kishi S. Correlation between visual acuity and foveal microstructural changes in diabetic macular edema. Retina. 2010;30:774-80.

Kanra AY, Ardagil Akçakaya A, Arı Yaylalı S, et al. The efficacy and safety of intravitreal dexamethasone implant for the treatment of macular edema related to retinal vein occlusion: real-life data and prognostic factors in a Turkish population. Turk J Ophthalmol. 2017;47:331-7.

Coscas G, Coscas F, Zucchiatti I, et al. SD-OCT pattern of retinal venous occlusion with cystoid macular edema treated with Ozurdex. Eur J Ophthalmol. 2011;21:631-6.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: 4
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

The effect of caffeic acid phenethyl ester (CAPE) on hepatic histopathology and oxidative stress in rats treated with malathion

GÖKHAN NUR, MEHMET TAHİR HÜSUNET, İZZETTİN GÜLER, Ayla DEVECİ, EVREN KOÇ, Ozlem NUR, PINAR AKSU KILIÇLE

Sociodemographic and pathological characteristics of women who underwent endometrial curettage for abnormal uterine bleeding in a university referral center

Fatma BEYAZIT, Buket AYDIN, Eren PEK, Mesut ÜNSAL

The role of tubes with preservative in urinalysis of pregnant women

ESİN AVCI, HÜLYA AYBEK, Zeliha KANGAL, Nihan ÇEKEN, İzzet Göker KÜÇÜK, Yusuf GEZER

Incidence of venous air embolism and blood gas changes seen in infratentorial surgeries operated in sitting position

Şennur UZUN, MURAT İZGİ, Aysun ANKAY-YILBAŞ, Nazgol Lotfi NAGHSH, Ülkü AYPAR

Oral electric injury in a child as a result of a home accident

Mehmet Tahir GÖKDEMİR, Özgür SÖĞÜT, Halil KAYA, Hasan BÜYÜKASLAN, Mehmet Özgür ERDOĞAN

Mid-term functional results of surgically treated acetabulum fractures

Cem Dinçay BÜYÜKKURT, Haluk ÇABUK, ALİ YÜCE, Ali Çağrı TEKİN, Murat ÇAKAR, HAKAN GÜRBÜZ

Restoration of photoreceptor layer and its prognostic value in eyes with macular edema due to branch retinal vein occlusion

Alper Halil BAYAT, Selim BÖLÜKBAŞI, Akın ÇAKIR, Burak ERDEN, Şeyma Gülcenur ÖZTURAN, Mustafa Nuri ELÇİOĞLU

Measurement uncertainty in biochemical parameters

Selda TELO, Dilara KAMAN

The effects of proprioceptive neuromuscular facilitation, myofascial releasing maneuvers and home exercises on pain and jaw function in patients with bruxism

ELİSA ÇALIŞGAN, BURCU TALU, Oğuzhan ALTUN, Numan DEDEOĞLU, ŞUAYİP BURAK DUMAN

The effect of ferulic acid against cisplatin-induced ototoxicity

FAZİLE NUR EKİNCİ AKDEMİR, MUSTAFA SITKI GÖZELER, Serkan YILDIRIM, Seda AŞKIN, Muhammet Bahaeddin DÖRTBUDAK, AHMET KIZILTUNÇ