The aim of this study is to reveal effect of Argan oil on postoperative peritoneal adhesion. Twenty-four Wistar albino rats were divided into three groups. After laparotomy was carried out intraperitoneally, 0,9% NaCl and 3 ml Argan Oil applied to saline and Argan oil groups, respectively. Four subjects in each groups were sacrificed at postoperative day 3 and 7. Macroscopic adhesions and microscopic cellular reactions, such as giant cell, lymphocyte/plasmocyte, neutrophil and histiocyte, were assessed and hydroxyproline levels were measured in all three groups. Adhesion and fibrosis scores were lower both 3rd and 7th days in Argan oil, but only lower fibrosis scores were statistically significant (p
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Menzies D. Postoperative adhesions: their treatment and relevance in clinical practice. Ann R Coll Surg Engl. 1993;75:147–53.
Cheong YC, Laird SM, Li TC, et al. Peritoneal healing and adhesion formation/reformation. Hum Reprod Update. 2001;7:556-66.
Buţureanu SA, Buţureanu TA. Pathophysiology of adhesions.Chirurgia (Bucur). 2004;109:293-8.
Arung W, Meurisse M, Detry O.Pathophysiology and prevention of postoperative peritoneal adhesions. World J Gastroenterol. 2011;17:4545-53.
Sartelli M, Griffiths EA,Nestori M. The challenge of post-operative peritonitis after gastrointestinal surgery. Updates Surg. 2015;67:373-81.
Brian C. Ward, Alyssa Panitch.Abdominal adhesions: current and novel therapies. J Surg Res. 2011;165:91-111.
Aysan E, Bektas H, Kaygusuz A, et al. A new approach for decreasing postoperative peritoneal adhesions: preventing peritoneal trauma with soybean oil. J Invest Surg. 2009;22:275-80.
Altınel Y, Taşpınar E, Ozgüç H, et al. The protective effect of ClinOleic against post-surgical adhesions. Ulus Travma Acil Cerrahi Derg. 2014;20:1-6.
Yigitler C, Karakas DO, Kucukodaci Z, et al. Adhesion-preventing properties of 4% icodextrin and canola oil: a comparative experimental study. Clinics (Sao Paulo). 2012;67:1303-8.
Karakas DO, Yigitler C, Gulec B, et al. Comparison of 4 % Icodextrin and Omega 3 Fatty Acids in Prevention of Peritoneal Adhesions. Indian J Surg. 2014;76:181-6.
De la Portilla F, Ynfante I, Bejarano D, et al. Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in rats. Dis Colon Rectum. 2004;47:2157-61.
Haimeur A, Messaouri H, Ulmann L, et al. Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation, enhancing oxidative status in dyslipidemic patients from the area of Rabat (Morocco). Lipids Health Dis. 2013;12:107.
Monfalouti HE, Guillaume D, Denhez C, et al. Therapeutic potential of argan oil: a review. J Pharm Pharmacol. 2010;62:1669-75.
Avsar U, Halici Z, Akpinar E, et al. The Effects of Argan Oil in Second-degree Burn Wound Healing in Rats. Ostomy Wound Manage. 2016;62:26-34.
Blauer KL, Collins RL. The effect of intra peritoneal progesterone on postoperative adhesion formation in rabbit. Fertil Steril. 1988;49:144-9
Delaco PA, Stefanetti M, Pressato D, et al. A novel hyaluronan-based gel in laparoscopic adhesion prevention: preclinical evaluation in an animal model. Fertil Steril. 1998;69:318-23
Ellis H, Moran BJ, Thompson JN, Pet al. Adeshion-releated hospital readmissions after abdominal and pelvic surgey: a retrospective cohort study. Lancet. 1999;353:1476-80.
Haney AF, Doty E. The formation of coalescing peritoneal adhesions requires injury to both contacting peritoneal surfaces. Fertil Steril. 1994;61:767-75.
Atta, HM. Prevention of peritoneal adhesions: a promising role for gene therapy. World J Gastroenterol. 2011;17:5049-58.
Karaca G, Aydin O, Pehlivanli F, et al. Effect of ankaferd blood stopper in experimental peritoneal adhesion model. Ann Surg Treat Res. 2016; 90:2137.
Charrouf Z, Guillaume D. Argan oil, the 35-years-of-research product. Eur. J. Lipid Sci. Technol. 2014;116:1316-21.
Jiang Q, Ames BN. Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J. 2003;17:816-22.
Higazi AA, Aziza R, Samara AA, et al. Regulation of fibrinolysis by nonesterified fatty acids. Biochem J. 1994;300:251-5.
Bonacci G, Schopfer FJ, Batthyany CI, et al. Electrophilic fatty acids regulate matrix metalloproteinase activity and expression. J Biol Chem. 2011;286:16074-81.