Relationship between thyrotropin and BMI in patients with subclinical hypothyroidism

Subclinical hypothyroidism is an asymptomatic illness characterized by elevated serum thyrotropin and normal values of thyroid hormones. Currently, epidemiological studies have suggested a positive relationship between serum thyrotropin and body mass index, although the primary source of this relationship is unknown. The aim of this study was to determine whether serum thyrotropin concentrations are associated with body mass index in patients with subclinical hypothyroidism. This is an observational, cross-sectional and analytical study, carried out in the Mexican Social Security Institute’s General Hospital No. 1 in Chihuahua. Weight, height, concentrations of serum thyrotropin, age, sex and smoking status data were collected from the clinical records of 128 patients diagnosed with subclinical hypothyroidism. We found that in higher categories of BMI we found higher means of serum thyrotropin: 5.92 μIU/mL for normal BMIs, 6.14 μIU/mL for overweight, 6.41 μIU/mL for obesity class I, and 7.03 μIU/mL for obesity classes II and II, P for trend

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1. Hill JO, Wyatt HR, Peters JC. Energy balance and obesity. Circulation. 2012;126(1):126-32.

2. Zhang Y, Liu J, Yao J, Ji G, Qian L, Wang J, Zhang G, Tian J, Nie Y, Zhang YE, Gold MS, Liu Y. Obesity: pathophysiology and intervention. Nutrients. 2014;6(11):5153-83.

3. WHO: Obesity and overweight. http://www.who.int/mediacentre/factsheets/fs311/en/. access date 06.07.2016

4. Sakurai M, Nakamura K, Miura K, Yoshita K, Takamura T, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y,Nakashima M, Nogawa K, Suwazono Y, Nakagawa H.. Association between a Serum Thyroid-stimulating Hormone Concentration within the Normal Range and Indices of Obesity in Japanese Men and Women. Intern Med. 2014;53(7):669-74.

5. Solanki A, Bansal S, Jindal S, Saxena V, Shukla US. Relationship of serum thyroid stimulating hormone with body mass index in healthy adults. Indian J Endocrinol Metab. 2013;17(Suppl1):S167-S9.

6. Nyrnes A, Jorde R, Sundsfjord J. Serum TSH is positively associated with BMI. Int J Obes. 2006;30(1):100-5.

7. Milionis A, Milionis C. Correlation between Body Mass Index and thyroid function in euthyroid individuals in Greece. ISRN Biomarkers. 2013;2013:7.

8. Hoogwerf BJ, Nuttall FQ. Long-term weight regulation in treated hyperthyroid and hypothyroid subjects. Am J Med. 1984;76(6):963- 70.

9. Tseng F-Y, Lin W-Y, Li C-I, Li T-C, Lin C-C, Huang K-C. Subclinical hypothyroidism is associated with increased risk for cancer mortality in adult Taiwanese-a 10 years population-based cohort. PLoS ONE. 2015;10(4):e0122955.

10. Danese MD, Ladenson PW, Meinert CL, Powe NR. Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. The J Clin Endocrinol Metab. 2000;85(9):2993-3001.

11. Singh S, Duggal J, Molnar J, Maldonado F, Barsano CP, Arora R. Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis. Int J Cardiol. 2008;125(1):41-8.

12. UCLA: How can I interpret log transformed variables in terms of percent change in linear regression? http://www.ats.ucla.edu/stat/stata/ado/analysis/. access date 06.07.2016

13. WHO: BMI classification. http://apps.who.int/bmi/index.jsp?introPage=intro_3.html access date 06.07.2016

14. Gupta G, Itagappa M, Kumar P, Sharma R, Sharma P. A Correlation Between Thyroid Stimulating Hormone And Body Mass Index In Women With Subclinical Hypothyroidism In Ncr. Asian J Pharm Clin Res. 2015;8(4):206-8.

15. Montoya-Morales DS, de los Angeles Tapia-Gonzalez M, AlamillaLugo L, Sosa-Caballero A, Munoz-Solis A, Jimenez-Sanchez M. [Alterations of the thyroid function in patients with morbid obesity]. Rev Med Ins Me Seguro Soc. 2015;53 Suppl 1:S18-22.

16. Gesing A, Lewiński A, Karbownik-Lewińska M. The thyroid gland and the process of aging; what is new? Thyroid Res. 2012;5(1):1-5.

17. Mungreiphy NK, Kapoor S, Sinha R. Association between BMI, Blood Pressure, and Age: Study among Tangkhul Naga Tribal Males of Northeast India. Journal of Anthropology. 2011;2011:6.

18. Valyasevi RW, Harteneck DA, Dutton CM, Bahn RS. Stimulation of adipogenesis, peroxisome proliferator-activated receptor-gamma (PPARgamma), and thyrotropin receptor by PPARgamma agonist in human orbital preadipocyte fibroblasts. J Clin Endocrinol Metab. 200,2;87(5):2352-8.

19. Feldt-Rasmussen U. Thyroid and leptin. Thyroid. 2007;17(5):413-9.

20. Rotondi M, Leporati P, La Manna A, Pirali B, Mondello T, Fonte R, Magri F, Chiovato L. Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism? Eur J Endocrinol. 2009;160(3):403-8.

21. Verma A, Jayaraman M, Kumar HK, Modi KD. Hypothyroidism and obesity. Cause or effect? Saudi Med J. 2008;29(8):1135-8.

22. Sanyal D, Raychaudhuri M. Hypothyroidism and obesity: An intriguing link. Indian J Endocrinol Metab. 2016;20(4):554-7.

23. Figueroa B, Velez H, Irizarry-Ramirez M. Association of thyroidstimulating hormone levels and body mass index in overweight Hispanics in Puerto Rico. Ethn Dis. 2008;18(2 Suppl 2):S2-151-4.