Hakan OGUTLU, İbrahim TİRYAKİ, İbrahim Selçuk ESİN, ONUR BURAK DURSUN

Psychiatric aspects of 47, XYY (Jacobs) syndrome: A case report

In this case, psychiatric aspects of 47, XYY syndrome is discussed in a male adolescent patient diagnosed with Attention Deficit Hyperactivity Disorder (ADHD), conduct disorder (CD), mild intellectual disability, and Tourette syndrome. A 13-year-old boy was diagnosed with ADHD, CD, mild intellectual disability, Tourette syndrome, and 47, XYY syndrome. As in our case, the presence of the XYY syndrome with Tourette syndrome, ADHD, CD and mild intellectual disability is the first demonstrative case. As it is known that XYY syndrome can often lead to neurodevelopmental disorders, genetic counseling can be provided when more than one neurodevelopmental disorders are detected as comorbid.

PDF

___

Hook EB. Behavioral implications of the human XYY genotype. Science. 1973;179(4069):139-50.

Kolaitis G, Bouwkamp CG, Papakonstantinou A, et al. A boy with conduct disorder (CD), attention deficit hyperactivity disorder (ADHD), borderline intellectual disability, and 47, XXY syndrome in combination with a 7q11. 23 duplication, 11p15. 5 deletion, and 20q13. 33 deletion. Child Adolesc Psychiatry Ment Health. 2016;10(1):33.

Geerts M, Steyaert J, Fryns JP. The XYY syndrome: a follow-up study on 38 boys. Genet Couns. 2002;14(3):267-9.

Bloom B, Cohen RA, Freeman G. Summary health statistics for U.S. children: national health interview survey, 2009. Vital Health Stat. 2010;10:1–82.

Boyle CA, Boulet S, Schieve LA, et al.Trends in the prevalence of developmental disabilities in US Children, 1997–2008. Pediatrics. 2011;127(6):1034-42.

Polanczyk G, de Lima MS, Horta BL, et al. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007;164:942–8.

Lewis, ME. Child and adolescent psychiatry: A comprehensive textbook. Lippincott Williams & Wilkins Publishers. 2002.

Cordeiro L, Tartaglia N, Roeltgen D, et al. Social deficits in male children and adolescents with sex chromosome aneuploidy: a comparison of XXY, XYY, and XXYY syndromes. Res Dev Disabil. 2012;33(4):1254-63.

Merskey H. A case of multiple tics with vocalisation (partial syndrome of Gilles de la Tourette) and XYY karyotype. Br J Psychiatry. 1974;125(589):593-4.

Soderstrom H, Sjodin AK, Carlstedt A, et al. Adult psychopathic personality with childhood-onset hyperactivity and conduct disorder: a central problem constellation in forensic psychiatry. Psychiatry res. 2004;12(3) 271-80.