Central serous chorioretinopathy (CSCR) is a posterior segment disorders characterized by localized and limited serous retinal detachment and/or retinal pigment epithelium detachment. The etiopathogenesis has not been fully elucidated. Local or systemic steroid administration through various routes and endogenous steroid increase are known to cause CSCR. It is believed that steroids cause CSCR development by delaying the healing of retinal pigment epithelium or increase choriocapillaris permeability through various mechanisms. The role of an allergic reaction in CSCR development is controversial. We evaluated a case that developed CSCR following a single intramuscular injection of 8 mg dexamethasone (Dekort, Deva) for a bee sting in this study. The systemic steroid dose used in our case was much lower than other doses reported to cause CSCR in the literature. This suggests that some molecules in the bee venom may have contributed to CSCR development in our case.
___
Daruich A, Matet A, Dirani A, et al. Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis. Prog Retin Eye Res. 2015;48:82-118.
Wang M, Munch IC, Hasler PW, et al. Central serous chorioretinopathy. Acta Ophthalmol. 2008;86(2):126-45.
Zakir SM, Shukla M, Simi Z, et al. Serum cortisol and testesterone levels in idiopathic central serous chorioretinopathy. Indian J Ophthalmol. 2009;57(6):419-22.
Bouzas EA, Karadimas P, Pournaras CJ. Central serous chorioretinopaty and glucocorticoids. Surv Ophthalmol. 2002;47(5):431-48.
Levy J, Marcus M, Belfair N, et al. Central serous chorioretinopathy in patients receiving systemic corticosteroid therapy. Can J Ophthalmol. 2005;40(2):217-21.
Tsai DC, Chen SJ, Huang CC, et al. Risk of central serous chorioretinopathy in adults prescribed oral corticosteroids: a population-based study in Taiwan.. Retina. 2014;34(9):1867-74.
Koyama M, Mizota A, Igarashi Y, et al. Seventeen cases of central serous chorioretinopathy associated with systemic corticosteroid therapy. Ophthalmologica. 2004;218(2):107-10.
Chaine G1, Haouat M, Menard-Molcard C, et al. Central serous chorioretinopathy and systemic steroid therapy. J Fr Ophthalmol. 2001;24(2):139-46.
Clarck RF. Hymenoptera. In: Olson KR, edition. Poisoning and Drug Overdose, 4th edition, NewYork Lange Medical Books/McGrawHill. 2004;225-6.
Edalati K, Roesch MT, Buchanan ML, et al. Central serous chorioretinopathy and idiopathic nonhistaminergic angioedema. Can J Ophthalmol. 2009;44(5):606-7.