Effects of age, gender, BMI, settlement and smoking on lead and cadmium accumulation in heart tissue

Cadmium (Cd) and lead (Pb) are well-known risk factors for peripheral arterial and some other cardiovascular diseases. The aim of the study was to determine the level of both toxic metals, in the human heart tissue and compare the accumulation to their age, gender, body mass index, living environment and smoking habit. Heart tissues of the 112 autopsy cases, representing a sample set of population living in capital city of Turkey: Ankara Province (both in city center and suburban), were collected from Turkey Ministry of Justice, Council of Forensic Medicine in Ankara Branch. Lead and cadmium analysis was carried out by Graphite Furnace Atomic Spectrometry technique. Cd/Pb results and individuals’ information were assessed by SPSS statistically. Average value of Pb was found as 1374.99±237.01ppb and Cd was found as 287.54±66.43ppb in all heart tissue samples. Consideration of metal levels in autopsy heart tissues by age, statistically significant positive correlation in Cd was observed (p

___

1. Olsson IM, Bensryd I, Lundh T, Ottosson H, Skerfving S, Oskarsson A. Cadmium in blood and urine–impact of sex, age, dietary intake, iron status, and former smoking–association of renal effects. Environ Health Perspect. 2002;110:1185-90.

2. ATSDR Agency for Toxic Substances and Disease Registry, Toxicological Profile for Cadmium. U.S. Department of Health and Human Services. Public Health Service 1999a

3. ATSDR Agency for Toxic Substances and Disease Registry, Toxicological Profile for Cadmium. U.S. Department of Health and Human Services. Public Health Service 2012

4. Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure-A review of the literature and a risk estimate. Scand J Work Environ Health. 1998;24(Suppl. 1):1-51.

5. Järup L, Akesson A. Current status of Cd as an environmental health problem. Toxicol Appl Pharmacol. 2009;238:201-8.

6. Peters JL, Perlstein TS, Perry MJ, McNeely E, Weuve J. Cadmium exposure in association with history of stroke and heart failure. Environ Res. 2010;110(2):199-206.

7. Nishijo M, Nakagawa H, Morikawa Y, Tabata M, Senma M, Miura K, Takahara H, Kawano S, Nishi M, Mizukoshi K. Mortality of inhabitants in an area polluted by cadmium: 15 year follow up. Occup Environ Med. 1995;52(3):181-4.

8. Carmignani M, Boscolo P. Cardiovascular responsiveness to physiological agonists of male rats made hypertensive by long-term exposure to cadmium. Sci Total Environ. 1984;34(1-2):19-33.

9. Ronco AM, Montenegro M, Castillo P, Urrutia M, Saez D, Hirsch S, Zepeda R, Llanos MN. Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring. Toxicol Appl Pharmacol. 2011;251(2):137-45.

10. Zepeda R, Castillo P, Saez D, Llanos MN, Ronco AM. Cardiac tissue injury resistance during myocardial infarction at adulthood by developmental exposure to cadmium. Cardiovas Toxicol. 2012;12(1):64-72.

11. Turdi S, Sun W, Tan Y, Yang X, Cai L and Ren J. Inhibition of DNA methylation attenuates low-dose cadmium-induced cardiac contractile and intracellular Ca2+ anomalies. Clinical and Experimental Pharmacology and Physiology. 2013;40(10):706-12.

12. Tellez-Plaza M, Navas-Acien A, Menke A, Crainiceanu CM, PastorBarriuso R, Guallar E. Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general population. Environ. Health Perspect. 2012;120(7):1017-22.

13. Krantz A, Dorevitch S. Metal exposure and common chronic diseases: a guide for the clinician. Disease-a-Month. 2004;50(5):220-62.

14. Carocci A, Catalano A, Lauria G, Sinicropi MS, Genchi G. Lead Toxicity, Antioxidant Defense and Environment Reviews of Environmental Contamination and Toxicology 2016;238:45-67.

15. Markowitz M. Lead poisoning. Pediatr Rev. 2000;21:327-35.

16. Begovic V, Nozic D, Kupresanin S, Tarabar D. Extreme gastric dilation caused by chronic lead poisoning: a case report. World J Gastroenterol. 2008;14(16):2599-01.

17. Lyn Patrick, ND Lead Toxicity, A Review of the Literature.Part I: Exposure, Evaluation, and Treatment Alternative Medicine Review. 2006;11(1):1-22.

18. Aoki Y, Brody DJ, Flegal KM, Fakhouri THI, Parker JD, Axelrad DA. Blood Lead and Other Metal Biomarkers as Risk Factors for Cardiovascular Disease Mortality. Medicine. 2016:95(1):1-8.

19. Vaziri ND, Lin CY, Farmand F, Sindhu RK. Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead induced hypertension. Kidney Int. 2003;63(1):186-94.

20. Fanning D. A mortality study of lead workers, 1926-1985. Arch Environ Health. 1988;43(3):247-51.

21. Sokas RK, Simmens S, Sophar K. Lead levels in Maryland construction workers. Am J Ind Med. 1997;31(2):188-94.

22. Staessen JA, Bulpitt CJ, Fagard R. Hypertension caused by lowlevel lead exposure: myth or fact? J Cardiovasc Risk. 1994;1(1):87- 97.

23. Schwartz J. Lead, blood pressure, and cardiovascular disease in men. Arch Environ Health. 1995;50(1):31-7.

24. Nawrot TS, Tiils L, Den Hond, EM. An epidemiological reappraisal of the association between blood pressure and blood lead: a metaanalysis. J Hum Hypertens. 2002;16(2):123-31.

25. Lustberg M, Silbergeld E. Blood lead levels and mortality. Arch Intern Med. 2002;162(2):2443-9.

26. Navas-Acien A, Selvin E, Sharrett AR, Calderon-Aranda E, Silbergeld E, Guallar E. Lead, cadmium, smoking, and increased risk of peripheral arterial disease. Circul. 2004;109(25):3196-201.

27. Lukkhananan P, Thawonrachat N, Srihirun S, Swaddiwudhipong W, Chaturapanich G, Vivithanaporn P, Unchern S, Visoottiviseth P, Sibmooh N. Endothelial dysfunction in subjects with chronic cadmium exposure. J Toxicol Sci. 2015;40(5):605-13.

28. National Center for Health Statistics. National Health and Nutrition Examination Survey, 1999–2000. Hyattsville, MD: National Center for Health Statistics, 2004. (http://www.cdc.gov/nchs/about/major/nhanes/nhanes99-00.htm)

29. Bridges CC, Zalups RK. Molecular and ionic mimicry and the transport of toxic metals. Tox Appl Pharm. 2005;204:274-308.

30. Zalups RK. Ahmad S. Molecular handling of cadmium in transporting epithelia. Tox Appl Pharm. 2003;186 (3):163-88.

31. Prozialeck WC, Edwards JR, Woods JM. The vascular endothelium as a target of cadmium toxicity. Life Sci. 2006;79(16):1493-506.

32. Gonick HC, Ding Y, Bondy SC, Ni Z, Vaziri ND. Lead-induced hypertension: interplay of nitric oxide and reactive oxygen species. Hypertension. 1997;30(6):1487-92.

33. Bhatnagar A. Environmental Cardiology:Studying Mechanistic Links Between Pollution and Heart Disease. Circulation Research. 2006;99(7):692-705.

34. Iwao S, Tsuchiya K, Sugita M. Variation of cadmium accumulation among Japanese.Arch Environ Health. 1983;38(3):156-62.

35. CDC. Fourth Report on Human Exposure to Environmental Chemicals. Centers for Disease Control and Prevention. US Department of Health and Human Services. Atlanta, GA. 2009.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Risk factors for mortality in delayed intertrochanteric fractures

Haluk ÇABUK, Cem Dinçay BÜYÜKKURT, Ali Çağrı TEKİN, Süleyman Semih DEDEOĞLU, Yunus İMREN, Yasin GULER, HAKAN GÜRBÜZ

Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in peritoneal dialysis patients

İbrahim ORMAN, HÜLYA TAŞKAPAN, MEHMET ÇAĞATAY TAŞKAPAN, Fatma ÖZYALIN, İrfan KUKU

Comparison of diffusion-weighed MRI findings of the testis in patients with the advanced stage unilateral testicular varicocele

Veysel BURULDAY, MEHMET HAMDİ ŞAHAN, Gülnur ERDEM, Ercan YUVANÇ

The importance of morel-lavallee lesion in medicolegal evaluation: a case report

Ahsen KAYA, Muhammed Emin GOKSEN, Ugur ATA, Ekin Özgür AKTAŞ

Isolated unilateral hypoglossal nerve paralysis: a case report

MEHMET GÜNEY ŞENOL, Mustafa ERKAN, HAKAN TEKELİ, Tansel KENDİRLİ

Quantum dots wide absorption pattern, photo stability and greater quantum yields provides a gate way to power full applications in nano medicine and nano biotechnology

Abilash ..

Caveolin-1 gene expression in rats model of chronic renal failure

Berna ÖZYAZGAN, Müslüm AKGÖZ, Yılmaz ÇİĞREMİŞ

Distal symmetrical polyneuropathy due to organophosphate intoxication

Semih ALAY, MEHMET GÜNEY ŞENOL, Tansel KENDİRLİ, RİFAT ERDEM TOĞROL, Mehmet SARAÇOĞLU

Palliative care and intensive care integration

Kadriye KAHVECİ

Apple peel atresia: a rare case of a small premature infant

Mehmet Şah İPEK, Mehmet ÖZER