Serkan BODUR, Mine Kanat PEKTAŞ, Vuslat Lale BAKIR, Mehmet Ferdi KINCI, İbrahim ALANBAY, Özgür DÜNDAR

Considerations on pathophysiology of primary dysmenorrhea under the light of alterations in complete blood count parameters

The present study strives to evaluate how the components of complete blood count are altered in women with primary dysmenorrhea. This is a cross-sectional analysis of 155 women with primary dysmenorrhea and 155 women without dysmenorrhea. The primary dysmenorrhea and control groups were matched with respect to age and body mass index. When compared with the controls, the women with primary dysmenorrhea had a significantly younger menarche age, longer menstrual duration, higher leukocyte counts, higher neutrophil counts, and elevated MPV values (p=0.010, p=0.022, p=0.014, p=0.011 and p=0.04 respectively). The logistic regression analysis demonstrated that women with primary dysmenorrhea were more likely to have a younger menarche age (OR=2.14, 95% CI=0.971-3.346, p=0.018), longer menstrual duration (OR=1.91, 95% CI=0.988-2.308, p=0.044), higher leukocyte counts (OR= 2.90, 95% CI=1.040-3.788, p=0.007), and elevated MPV values (OR=3.17, 95% CI=2.056-9.128, p=0.001). The sensitivity and specificity of this model were 84.6% and 77.3%, respectively. Leukocytosis and increased MPV are might be associated with the inflammatory and vasoconstrictory pathogenesis of primary dysmenorrhea, but this result should be confirmed in the future researches

PDF

___

1. Harada T. Dysmenorrhea and endometriosis in young women. Yonago Acta Med. 2013;56(4):81-4.

2. Allen LM, Lam AC. Premenstrual syndrome and dysmenorrhea in adolescents. Adolesc Med State Art Rev 2012;23(1):139-63.

3. Harel Z. Dysmenorrhea in adolescents. Ann N Y Acad Sci. 2008;1135:185- 95.

4. Sultan C, Gaspari L, Paris F. Adolescent dysmenorrhea. Endocr Dev. 2012;22:171-80.

5. Morrow C, Naumburg EH. Dysmenorrhea. Prim Care 2009;36(1):19-32.

6. Harel Z. Dysmenorrhea in adolescents and young adults: from pathophysiology to pharmacological treatments and management strategies. Expert Opin Pharmacother. 2008;9(15):2661-72.

7. Ju H, Jones M, Mishra G. The prevalence and risk factors of dysmenorrhea. Epidemiol Rev. 2014;36(1):4-13.

8. Ortiz MI, Rangel-Flores E, Carrillo-Alarcón LC, Veras-Godoy HA. Prevalence and impact of primary dysmenorrhea among Mexican high school students. Int J Gynaecol Obstet. 2009;107(3):240-3.

9. Harel Z. Dysmenorrhea in adolescents and young adults: an update on pharmacological treatments and management strategies. Expert Opin Pharmacother. 2012;13(15):2157-70.

10. Harel Z. Dysmenorrhea in adolescents and young adults: etiology and management. J Pediatr Adolesc Gynecol. 2006;19(6):363-71.

11. Sadik CD, Kim ND, Luster AD. Neutrophils cascading their way to inflammation. Trends Immunol. 2011;32(10):452-60.

12. Dmitrovic R, Kunselman AR, Legro RS. Sildenafil citrate in the treatment of pain in primary dysmenorrhea: a randomized controlled trial. Hum Reprod. 2013;28(11):2958-65.

13. Mrugacz G, Grygoruk C, Sieczyński P, Grusza M, Bołkun I, Pietrewicz P. Etiopathogenesis of dysmenorrhea. Med Wieku Rozwoj. 2013;17(1):85-9.

14. Harel Z. A contemporary approach to dysmenorrhea in adolescents. Paediatr Drugs. 2002;4(12):797-805.

15. Abu JI, Konje JC. Leukotrienes in gynaecology: the hypothetical value of anti-leukotriene therapy in dysmenorrhoeaand endometriosis. Hum Reprod Update. 2000;6(2):200-5.

16. Valentin L, Sladkevicius P, Kindahl H. Effects of a vasopressin antagonist in women with dysmenorrhea. Gynecol Obstet Invest. 2000;50(3):170-7.

17. Ulrich C, Quillici DR, Schegg K, Woolsey R, Nordmeier A, Buxton IL. Uterine smooth muscle S-nitrosylproteome in pregnancy. Mol Pharmacol. 2012;81(2):143-53.

18. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation. Current Pharmaceutical Design. 2011;17(1):47-58.

19. Duygu H, Turkoglu C, Kirilmaz B, Turk U. Effect of mean platelet volume on post-intervention coronary blood flow in patients with chronic stable angina pectoris. J Invasive Cardiol. 2008;20(3):120-4.

20. Yasar AS, Bilen E, Yuksel IO, Arslantas U, Karakas F, Kirbaş O, Bilge M. Association between admission mean platelet volume and coronary patency after thrombolytic therapy for acute myocardial infarction. Turk Kardiyol Dern Ars 2010; 38(2): 85-9.

21. Soydinc HE, Evsen MS, Sak ME, Ozler A, Turgut A, Gul T. Association between mean platelet volume and different phases of menstrual cycle in primary dysmenorrhea. Clin Exp Obstet Gynecol. 2013;40(3):429-32.

22. Dundar O, Yoruk P, Tutuncu L, Erikci AA, Muhcu M, Ergur AR, Atay V, Mungen E. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn. 2008;28(11):1052-6.