Thiol/disulfide homeostasis (TDH) is a new marker of oxidative stress. In this study, we would like to determine the changes in TDH in hemodialysis (HD) patients with chronic kidney disease (CKD). This cross-sectional study was conducted in the Nephrology Clinic of Konya Training and Research Hospital. A total of 197 individuals including 75 HD patients, 41 end stage renal disease (ESRD) patients (having stage 3-5 CKD but not receiving hemodialysis), and 81 healthy controls were enrolled in the study. Serum native thiol, total thiol, and disulfide levels were measured with a new method developed by Erel and Neselioglu. It was determined that there was a statistically significant difference in the mean age, body mass index (BMI), modification of diet in renal disease (MDRD), and creatinine level between the three groups (p
___
1. Thanan R, Oikawa S, Hiraku Y, et al. Oxidative stress and its significant roles in neurodegenerative diseases and cancer. Int J Mol Sci. 2014;16:193-217.
2. Libetta C, Sepe V, Esposito P, et al. Oxidative stress and inflammation: implications in uremia and hemodialysis. Clin Biochemistry. 2011;44:1189-98.
3. Spittle MA, Hoenich NA, Handelman GJ, et al. Oxidative stress and inflammation in hemodialysis patients. Am J Kidney Dis. 2001;38:1408-13.
4. Locatelli F, Canaud B, Eckardt KU, et al. Oxidative stress in end‐stage renal disease: an emerging threat to patient outcome. Nephrol Dial Transplant. 2003;18:1272-80.
5. Massy ZA, Stenvinkel P, Drueke TB. The role of oxidative stress in chronic kidney disease. Seminars in Dialysis. 2009;22:405-8.
6. Dounousi E, Papavasiliou E, Makedou A, et al. Oxidative stress is progressively enhanced with advancing stages of CKD. Am J Kidney Dis. 2006;48:752-60.
7. Himmelfarb J. Oxidative stress in hemodialysis. Hemodialysis-From Basic Research to Clinical Trials. 161: Karger Publishers; 2008. p. 132-7.
8. Noyan T, Avcı G, Şekeroğlu MR, et al. The Investigation of Relationship Between Secondary Hyperparathyroidism and Oxidative Stress in Patients with Chronic Kidney Disease. Turkish Nephrol, Dialysis Transplant J. 2009;9:11:69-75
9. Spittle M, Hoenich NA, Handelman G, et al. Oxidative stress and inflammation in hemodialysis patients. Improving Prognosis for Kidney Disorders: Springer; 2002. p. 45-52.
10. Tayebi Khosroshahi H, Vaziri ND, Abedi B, et al. Effect of high amylose resistant starch (HAM‐RS2) supplementation on biomarkers of inflammation and oxidative stress in hemodialysis patients: a randomized clinical trial. Hemodialysis Int. 2018.
11. LeGrand A, Fermor B, Fink C, et al. Interleukin‐1, tumor necrosis factor α, and interleukin‐17 synergistically up‐regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. Arthritis & Rheumatism: Official J Am College Rheumatol. 2001;44:2078-83.
12. Horton JW. Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy. Toxicology. 2003;189:75-88.
13. Solak I, Cetinkaya C, Gederet Y, et al. Effects of smoking on thiol/disulfide homeostasis. Eur Rev Med Pharmacol Sci. 2017;21:2477-82.
14. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145:247-54.
15. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical Biochemistry. 2014;47:326-32.
16. Bal C, Büyükşekerci M, Koca C, et al. The compromise of dynamic disulfide/thiol homeostasis as a biomarker of oxidative stress in trichloroethylene exposure. Human & Experimental Toxicology. 2016;35:915-20.
17. Ateş İ, Özkayar N, Yılmaz FM, et al. Oxidative stress level in patients with chronic kidney disease. Ortadogu Med J. 2018;10.
18. Prakash M, Upadhya S, Prabhu R. Protein thiol oxidation and lipid peroxidation in patients with uraemia. Scand J Clin Lab Invest. 2004;64:599-604.
19. Miyata T, Sugiyama S, Saito A, et al. Reactive carbonyl compounds related uremic toxicity (“carbonyl stress”). Kidney International. 2001;59:25-31.
20. Ates I, Kaplan M, Inan B, et al. How does thiol/disulfide homeostasis change in prediabetic patients? Diabetes Res Clin Pract. 2015;110:166-71.
21. Babaoglu E, Kilic H, Hezer H, et al. Comparison of thiol/disulphide homeostasis parameters in patients with COPD, asthma and ACOS. Eur Rev Med Pharmacol Sci. 2016;20:1537-43.
22. Shimobayashi M, Albert V, Woelnerhanssen B, et al. Insulin resistance causes inflammation in adipose tissue. J Clin Invest. 2018;128.
23. Sogut I, Aydın AS, Gokmen ES, et al. Evaluation of oxidative stress and thiol/disulfide parameters according to BMI in adult individuals. Erciyes Med J. 2018;40:155-61.