Sema AVCI, Sevinç ŞAHİN, Cemre Nur BALCI

Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus

Aim: This study aims to determine the role of IGF-1R in the etiology of sacrococcygeal pilonidal sinus and to evaluate the findings regarding its contribution to treatment. Material and Methods: The general structure of skin and connective tissue components in healthy and lesioned tissue sections of sacrococcygeal pilonidal sinus cases was evaluated by Masson trichrome staining. In addition, the expression of IGF-1R protein in healthy and pilonidal sinus tissue was determined by immunohistochemical staining. Results: It was observed that the epidermis of the pilonidal sinus was thinned compared to the healthy area, and the hair follicle structures and connective tissue components deteriorated. IGF-1R expression was significantly decreased in basal keratinocytes in sacrococcygeal pilonidal sinus tissues. Conclusion: It is thought that IGF-1R may be involved in the etiology of sacrococcygeal pilonidal sinus, and more data is needed in terms of its contribution to treatment.

Keywords:

Sacrococcygeal Pilonidal Sinus, IGF-1R, keratinocytes,

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