Diabetic foot is one of the chronic complications of diabetes mellitus. We performed synthetic skin replacement (Epigard) in diabetic ulcers in an attempt to evaluate its effect on diabetic wound healing. According to Wagner diabetic foot ulcer classification system, 174 patients with grade 1 and 2 ulcers were evaluated. All of the infected tissues were debrided then Epigard was applied. At the end of the 6th-8th day, Epigard was removed and a split-thickness skin graft was applied to the wound. If the granulation tissue was not good enough after the first application of Epigard second and third Epigard applications were performed. The ratio of the skin grafts which were kept vital after the first) second and third application of Epigard were 50.0 %, 19.5 % and 9.2 % respectively. Rapidly formed granulation tissue, a granulation tissue of higher quality and its increased viability chance of split-thickness grafting, caused a dramatic decrease in the number of amputations performed. Because of these reasons, Epigard can be one of the important treatment modalities for diabetic foot problems.