YAĞ DOKUSUNUN İŞLEVSEL SIRLARI

Yağ dokusu, karmaşık, önemli ve son derece aktif metabolik ve endokrin bir organdır. Yağ dokusu sadece trigliserit depolanması ile değil aynı zamanda besinsel, sinirsel ve hormonal sinyallere yanıt vererek ve beslenme, termogenez, bağışıklık ve nöroendokrin fonksiyonları kontrol eden adipokinlerin salgılanmasını sağlayarak enerji homeostazında önemli bir rol oynamaktadır. Yağ dokusu 'adipokinler' olarak adlandırılan otokrin, parakrin ve endokrin etkileri ile lokal olarak ve distalde etki gösteren biyoaktif peptidler salgılamaktadır. Adipokinler; leptin, adiponektin, rezistin, tümör nekroz faktör-alfa, interlökin-6, visfatin, apelin, adipsin, asilasyon uyarıcı protein, plazminojen aktivatör inhibitör-1, renin-anjiyotensin sistem proteinleri, metalotionin ve fasting-induced adipose faktör gibi hormonları kapsamaktadır. Bazı adiposit faktörlerin artmış üretimi ile obezitenin metabolik ve kardiyovasküler komplikasyonları arasında ciddi bir ilişki olduğu bulunmuştur. Özellikle iç organlardaki yağ dokusu fazlalığı veya obezite; insülin direnci, hiperglisemi, dislipidemi, hipertansiyon ve protrombotik ve proinflamatuar durumlar ile ilişkilidir. Bu derlemenin amacı adipoz dokunun endokrin fonksiyonlarını açıklamaktır

Anahtar Kelimeler:

Yağ dokusu, adipokinler, metabolizma

Secrets of Adipose Tissue Function

Adipose tissue is a complex, essential, and highly active metabolic and endocrine organ. Adipose tissue plays a critical role in energy homeostasis, not only in storing triglycerides, but also by secreting adipokines that control feeding, thermogenesis, immunity, and neuroendocrine function via responding to nutritional, neural, and hormonal signals. Adipose tissue secretes bioactive peptides, termed ‘adipokines', which act locally and distally through theirautocrine, paracrine and endocrine effects. Adipokines include hormones such as leptin, adiponectin, resistin, tumor necrosis factor-alpha, interleukin-6, visfatin, apelin, adipsin, acylation stimulating protein, plasminogen activator inhibitor-1, proteins of the renin-angiotensin system, metallothionein and fasting-induced adipose factor. There is already considerable evidence of links between increased production of some adipocyte factors and the metabolic and cardiovascular complications of obesity. Adipose tissue excess or obesity, particularly in the visceral compartment, is associated with insulin resistance, hyperglycemia, dyslipidemia, hypertension, and prothrombotic and proinflammatory states. The aim of this review presents an overview of the endocrine functions of adipose tissue.

Keywords:

Adipose tissue, adipokines, metabolism,

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Yrd. Doç. Dr. Gökhan CESUR
Adnan Menderes Üniversitesi Tıp Fakültesi,
Fizyoloji Anabilim Dalı, AYDIN, TÜRKİYE
salınan yeni adipokinler. Fırat Saglık Hizmetleri Dergisi 2011;6:17. E-Posta
: gokhancesur@hotmail.com
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