Erdal GEZER, Selda ŞEN, Bakiye UĞUR, Osman Nuri AYDIN, Mustafa OĞURLU, Feray GÜRSOY

REMİFENTANİL VE ALFENTANİLİN ENDOTRAKEAL ENTÜBASYONDA SPİROMETRİK PARAMETRELER ÜZERİNE OLAN ETKİLERİNİN DEĞERLENDİRİLMESİ

Amaç:Çalışmamızın amacı remifentanil ve alfentanil kullanılan hastalarda endotrakeal entübasyona yanıtolarak oluşan solunumsal değişikliklerin etkilerini spirometrik olarak araştırmaktır.Gereç ve yöntem:Çalışma retrospektif olarak hasta dosyalarındaki anestezi takip fişleri taranarak, genelanestezi altında opere olan 18-60 yaş arası 40 olgu seçilerek 2 eşit grup oluşturularak gerçekleştirildi.Remifentanil (Ultiva®,) grubunda (Grup R) remifentanil; entübasyondan önce 1 µg/kg İV bolus, entübasyondansonra 0.25 g/kg/dak. infüzyonla, alfentanil (Rapifen®) grubunda (Grup A) alfentanil; entübasyondan önce 20g/kg İV bolus ve entübasyondan sonra 1 g/kg/dak infüzyonla uygulanmış. İlaç verildikten sonra,µ entübasyondan hemen önce ve sonra, intraoperatif 5., 10. dakikalarda spirometreyle pik inspiratuvar basınç(PİP), plato basıncı (Pplato), havayolu direnci (Raw), akciğer kompliyans (C) değerleri kaydedilmiştir.Bulgular:Gruplar arasında pik inspiratuar basınç, plato basıncı, kompliyans değerleri arasında anlamlı farksaptanmazken; havayolu direnci bazal değerleri arasında alfentanil grubunda daha düşük olmak üzere istatikselolarak anlamlı fark saptandı (P

Anahtar Kelimeler:

Remifentanil, alfentanil, spirometrik parametreler

Evaluation of the Effects of Remifentanyl and Alfentanyl on Spirometric Parameters in Endotracheal Intubations

Objective: The aim of this study was to evaluate respiratory changes on spirometry which occur in response to endotracheal intubations in patients receiving remifentanyl and alfentanyl. Materials and methods: This is a retrospective study. Spirometric data were derived from anaesthesia monitoring forms in patient files. The study included 40 patients aged between 18 and 60 years. They were assigned into two groups i.e. Group remifentanyl (R) (n=20) and Group alfentanyl (A) (n=20). Group R received intravenous bolus 1 µg/kg remifentanyl before intubations and 0.25 µg/kg/min remifentanyl after intubations and Group A received IV bolus 20 µg/kg alfentanyl before intubations and 1 µg/kg/min alfentanyl after intubations. Peak inspiratory pressure (PIP), plateau pressure (Pplateau), airway resistance (Raw) and pulmonary compliance (C) measured just before and soon after Remifentanyl and Alfentanyl were given and in the intraoperative fifth and tenth minutes were obtained. Results: There was no significant difference in peak inspiratory pressure, plateau pressure and pulmonary compliance between the groups, but the difference in baseline airway resistance between the groups was significant (P

Keywords:

Remifentanyl, alfentanyl, spirometric parameters,

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