Protective Effect of Vitamin B5 (Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats

Objective: This study aimed to evaluate the effects of vitamin B5 [dexpanthenol, DEX] treatment on the kidney in a streptozotocin (STZ) diabetes animal model. Materials and Methods: Twenty-four Wistar rats were randomised in one of the four groups: Group 1 served as control, and group 2 was administered high-dose DEX (300 mg/kg/day) as a safety group. Diabetes was induced by intraperitoneal injection of a single dose of STZ (50 mg/kg) in groups 3 and 4. In group 4, DEX was administered as well. All groups were followed up for 6 weeks. Histopathological analyses were performed on renal tissue using periodic acid-Schiff and HematoxylinEosin stains. Results: Microscopic evaluation of the kidney revealed that the rats demonstrated kidney damage 6 weeks after STZ administration. However, high-dose and longterm DEX administration alone did not damage renal tissue; moreover, kidney damage was prevented if DEX was administered in the early phase of diabetes. Conclusion: DEX could be a safe and cost-effective vitamin for the prevention of diabetes complications.

Sıçanlarda B5 Vitamininin (Dekspantenol) Nefropatiye Etkisi

Amaç: Çalışmamızda streptozotosin (STZ) diyabet hayvan modelinde B5 [dexpanthenol (DEX)] vitamini ile tedavinin böbrek üzerindeki etkilerini değerlendirdik. Gereç ve Yöntemler: Yirmi dört wistar sıçanı dört gruba eşit ve randomize olarak dağıtıldı. Grup 1 kontrol grubu; grup 2 güvenlik grubu olarak yüksek doz DEX (300 mg/kg/gün) verildi. Diyabet, grup 3 ve 4’te tek bir intraperitoneal doz STZ (50 mg/ kg) enjeksiyonu ile oluşturuldu. Grup 4 DEX ile tedavi edildi. Tüm gruplar 6 hafta takip edildi. Periyodik asit Schiff ve Hematoksilen-Eosin kullanılarak böbrek dokusu üzerinde histopatolojik incelemeler yapıldı. Bulgular: Böbreğin mikroskobik değerlendirmesinde, sıçanlarda STZ müdahalesinden 6 hafta sonra böbrek hasarı geliştiği görüldü. Tek başına yüksek ve uzun süreli DEX uygulaması böbrek dokusu için zararlı değildi. Ayrıca diyabetin erken evresinde DEX verilmesi böbrek hasarını önledi. Sonuç: Diyabet komplikasyonlarını önlemek için DEX güvenli ve uygun maliyetli bir vitamin olabilir.

Kaynakça

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Kaynak Göster

Meandros Medical And Dental Journal
  • ISSN: 2149-9063
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2000

3.6b1.7b

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