Haematological Parameters in Children with Serum Folate Deficiency

Objective: Folate deficiency is common globally, especially in low- and middle income countries. The best-known morbid effects of folate deficiency are haematological in nature. This study aimed to identify the haematological parameters status of folate deficiency in children. Materials and Methods: Data were gathered from the outpatient clinics electronic database of Gaziantep University Hospital. A total of 200 children were evaluated. The inclusion criteria were paediatric patients with folate deficiency (

Serum Folat Eksikliği Olan Çocuklarda Hematolojik Belirteçler

Amaç: Folat eksikliği düşük ve orta gelirli ülkelerde yaygındır. Folat eksikliğinin en önemli morbid etkisi hematolojiktir. Bu çalışmanın amacı folat eksikliği olan çocuklarda hematolojik parametrelerin değerlendirilmesidir. Gereç ve Yöntemler: Bu çalışmanın verileri Gaziantep Üniversitesi Hastanesi ayaktan hasta klinikleri elektronik veri sisteminden toplanmıştır. İki yüz çocuk hasta değerlendirilmiştir. Folat eksikliği olan çocuk hastalar çalışmaya dahil edilmiştir (

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1. Pfeiffer CM, Hughes JP, Lacher DA, Bailey RL, Berry RJ, Zhang M, et al. Estimation of trends in serum and RBC folate in the U.S. population from pre- to postfortification using assay-adjusted data from the NHANES 1988-2010. J Nutr 2012; 142: 886-93.

2. Gomber S, Kumar S, Rusia U, Gupta P, Agarwal KN, Sharma S. Prevalence & etiology of nutritional anaemias in early childhood in an urban slum. Indian J Med Res 1998; 107: 269-73.

3. Modood-ul-Mannan, Anwar M, Saleem M, Wiqar A, Ahmad M. A study of serum vitamin B12 and folate levels in patients of megaloblastic anaemia in northern Pakistan. J Pak Med Assoc 1995; 45: 187-8.

4. Metz J. A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia. Food Nutr Bull 2008; 29: 74-85.

5. Green R, Jacobsen D. Clinical implications of hyperhomocysteinemia. Folate in Health and Disease 1995; 75: 8569.

6. Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Arch Intern Med 1999; 159: 1289-98.

7. de Benoist B. Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 2008; 29: 238-44.

8. Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other Causes. Med Clin North Am 2017; 101: 297-317.

9. Lubin BH. Reference values in infancy and childhood. In: Nathan DG, Oski FA, eds. Hematology of Infancy and Childhood, 4th ed. Philadelphia: WB Saunders; 1993: 1905-54.

10. Ndiaye NF, Idohou-Dossou N, Diouf A, Guiro AT, Wade S. Folate Deficiency and Anemia Among Women of Reproductive Age (15-49 Years) in Senegal: Results of a National Cross-Sectional Survey. Food Nutr Bull 2018; 39: 65-74.

11. Silva LL, Fawzi WW, Cardoso MA; ENFAC Working Group. Serum folate and vitamin B12 status in young Brazilian children. Public Health Nutr 2019; 22: 1223-31.

12. Villalpando S, Perez-Exposito AB, Shamah-Levy T, Rivera JA. Distribution of anemia associated with micronutrient deficiencies other than iron in a probabilistic sample of Mexican children. Ann Nutr Metab 2006; 50: 506-11.

13. Gupta RK, Sharma SD, Gupta R. Megaloblastic Anemia: Clinicohematologic Profile in 50 Children. J Med Science 2009; 12: 49-52.

14. Scott JM. Folate and vitamin B12. Proc Nutr Soc 1999; 58: 441-8.

15. Koury MJ, Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr 2004; 24: 105-31.

16. Azimi S, Faramarzi E, Sarbakhsh P, Ostadrahimi A, Somi MH, Ghayour M. Folate and vitamin B12 status and their relation to hematological indices in healthy adults of Iranians: Azar cohort study. Nutr Health 2019; 25: 29-36.

17. De Bruyn E, Gulbis B, Cotton F. Serum and red blood cell folate testing for folate deficiency: new features? Eur J Haematol 2014; 92: 354-9.

18. Qazi RA, Masood A. Diagnostic evaluation of Pancytopenia. J Rawal Med Coll 2002; 6: 30-3.

19. Erkurt MA, Berber I, Nizam I, Kaya E. Etiologic evaluation of 1012 patients admitted with throm bocytopenia. British J of Medicine &Medical Research 2014; 4: 103-14.

20. Dhoriya PS, Kaur S, Dhoriya GS, Gupta D, Garg B. Etiological Spectrum and Clinical Profile of Patients Admitted with Pancytopenia. Journal of Advances in Medicine and Medical Research 2020; 32: 56-65.

21. Kar M, Ghosh A. Pancytopenia. J Indian Acad Clin Med 2002; 3: 29-34.

22. Rogers LM, Boy E, Miller JW, Green R, Sabel JC, Allen LH. High prevalence of cobalamin deficiency in Guatemalan schoolchildren: associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations. Am J Clin Nutr 2003; 77: 433-40.

23. Bhatnagar SK, Chandra J, Narayan S, Sharma S, Singh V, Dutta AK. Pancytopenia in children: etiological profile. J Trop Pediatr 2005; 51: 236-9.

24. Talarmin F, Hugard L, Mion M, Sellier P, Charles D. Les pancytopénies carentielles [Vitamin deficiency pancytopenia]. Ann Med Interne (Paris) 1994; 145: 159-62.

25. Sarode R, Garewal G, Marwaha N, Marwaha RK, Varma S, Ghosh K, et al. Pancytopenia in nutritional megaloblastic anaemia. A study from north-west India. Trop Geogr Med 1989; 41: 331-6.

26. Gomber S, Kela K, Dhingra N. Clinico-hematological profile of megaloblastic anemia. Indian Pediatr 1998; 35: 55-8.

27. Mukiibi JM, Makumbi FA, Gwanzura C. Megaloblastic anaemia in Zimbabwe: spectrum of clinical and haematological manifestations. East Afr Med J 1992; 69: 83-7.
Meandros Medical And Dental Journal-Cover
  • ISSN: 2149-9063
  • Başlangıç: 2000
  • Yayıncı: Erkan Mor
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