ASEMPTOMATİK SAFRA KESESİ TAŞI OLAN HASTALARDA LAPAROSKOPİK KOLESİSTEKTOMİNİN GASTROİNTESTİNAL HAYAT KALİTESİ ÜZERİNE ETKİSİ
AMAÇ:Bu çalışmada asemptomatik kolelitiyazis olgularının ameliyat öncesi ve ameliyat sonrası hayat kalitesideğerlendirilmiştir.GEREÇ ve YÖNTEM:Hastaların ameliyat öncesi ve sonrası hayat kalitelerinin ölçümü gastrointestinal hayatkalitesi indeksi parametreleri kullanılarak belirlenmiştir.BULGULAR:Çalışmaya alınan 71 hasta ameliyat öncesi ve ameliyattan en az 3 ay sonra gastrointestinal hayatkalitesi indeksine göre sorgulanmıştır. Preoperatif dönemde ortalama skor 126.8±14.07, 3 ay sonra yapılansorgulamada ise ortalama 136.6±9.31 olup normal populasyona yakın bir oranda saptanmıştır. (toplam skor 144).Gastrointestinal semptomlarının yanı sıra fiziksel, sosyal ve duygusal durumlarında da anlamlı düzelmegözlenmiştir. Düşük skorlu hastalarda bu iyileşme daha belirgindir.SONUÇ:Asemptomatik kolelitiyazisli hastalarda başka gastrointestinal patolojilerle açıklanamayannonspesifik semptomların laparoskopik kolesistektomiyle iyileşme gösterdiği, hastaların hayat kalitelerindeanlamlı bir artış olduğu görülmektedir
Gastrointestinal Quality of Life in Patients with Asymptomatic Cholelithiasis After Laparoscopic Cholecystectomy
OBJECTIVE: To assess the outcome of laparoscopic cholecystectomy for asymptomatic cholelithiasis before and after laparoscopic cholecystectomy using a specific quality of life instrument for gastrointestinal disorders in adults. MATERIALS and METHODS: The Gastrointestinal Quality of Life Index (GIQLI) was studied before and after laparoscopic cholecystectomy. RESULTS: Seventy one patients completed the GIQLI questionnaire both preoperatively and after a minimum postoperative follow-up of three months. Mean preoperative score was 126.8±14.07 out of a theoretical maximum score of 144. After three months, the score had significantly improved to 136.6±9.31, close to the range for the normal population. Not only items assessing gastrointestinal symptoms but also the domains of physical, social, and emotional function improved significantly. The most marked improvements were achieved in patients with the lowest preoperative scores. CONCLUSION: Laparoscopic cholecystectomy significantly improves the quality of life in patients with cholelithiasis who are asymptomatic or have nonspecific gastrointestinal symptoms that cannot be explained by another gastrointestinal pathology.
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- 1. NIH consensus statement on gallstones and
laparoscopic cholecystectomy. National Institutes of
Health Consensus Development Conference
Statement, September 14-16, 1992.
- 2. Halldestam, Enell EL, Kullman E, Borch K.
Development of symptoms and complications in
individuals with asymptomatic gallstones. Br J Surg
2004;91(6):7348.
- 3. Capocaccia L, Giunchi G, Pocchiari F, Rome Group for
the Epidemiology and Prevention of Cholelithiasis
(GREPCO). Prevalence of gallstone disease in an
Italian adult female population. Am J Epidemiol
1984;119:796-805.
- 4. Mentes BB, Akin M, Tatlıcıoglu E, Ferahkose Z,
Yıldırım A, Maral I. Gastrointestinal quality of life in
patients with symptomatic or asymptomatic
cholelithiasis before and after laparoscopic
cholecystectomy. Turkey Surg Endosc 2001;15;1267-
72.
- 5. Patino JF, Quintero GA. Asymptomatic cholelithiasis
revisited.World J Surg 1998;22:1119-24.
- 6. Roslyn JJ. Calculous biliary disease. In: Greenfield LJ,
Mulholand MW, Oldham KT, Zelenock GB, editors.
Surgery: scientific principles and practice, Ist ed.
Philadelphia, 2001: 936-53.
- 7. Aufderheide TJ, Brady WJ, Tintinalli JE. Cholecystitis
and biliary colic. In: Tintinalli JE, Kelen GD,
Stapczynski S, editors. Emergency medicine, A
comprehensive study guide, 5th ed. International
Mcgraw Hill, USA, 2000: 576-80.
- 8. İnsel H, Göksoy E. Safra kesesi ve safra yollarının
anatomisi. In: Aybar S, editor. 1. Baskı, Genel cerrahi,
Nobel Kitabevi,İstanbul, 1991: 328 -59.
- 9. Keus F, Broeders IA, van Laarhoven CJ. Gallstone
disease: Surgical aspects of symptomatic
cholecystolithiasis and acute cholecystitis. Best Pract
Res Clin Gastroenterol 2006;20(6):1031-51.
- 10. Keus F, De Jong JA, Gooszen HG, Van Laarhoven CJ.
Laparoscopic versus open cholecystectomy for
patients with symptomatic cholecystolithiasis.
Cochrane Database Syst Rev 2006; (4):CD006231.
- 11. Finan KR, Leeth RR, Whitley BM, Klapow JC, Hawn
MT. Improvement in gastrointestinal symptoms and
quality of life after cholecystectomy. Am J Surg
2006;192 (2):196-202.
- 12. Eriksen JR, Kristiansen VB, Hjortsø NC, Rosenberg J,
Bisgaard T. Effect of laparoscopic cholecystectomy on
the quality of life of patients with uncomplicated
socially disabling gallstone disease. Ugeskr Laeger
2005;167 (24):2654-6.
- 13. Keus F, De Vries J, Gooszen HG, Van Laarhoven CJ.
Laparoscopic versus small-incision cholecystectomy:
Health status in a blind randomised trial. Surg Endosc
2008;22(7):1649-59.
- 14. Quintana JM, Arostegui I, Cabriada J, López I, Perdigo
L. Predictors of improvement in health-related quality
of life in patients undergoing cholecystectomy. Br J
Surg 2003;90:1549-55.
- 15. Ransohoff DF, William A. Treatment of gallstones.
Gracie Annals of Internal Medicine 1993;119(7): 606-
19.
- 16. Friedman GD. Natural history of asymptomatic and
symptomatic gallstones.Am J Surg 1993;165:399-404
- 17. Friedman GD, Raviola GA, Fireman, B. Prognosis of
gallstones with mild or no symptoms: 25 years followup in a health maintenance organisation. J Clin
Epidemol 1989:42;127-36.
- 18. Attili AF, De Santis A, Capri R, Repice AM, Maselli S.
The natural history of gallstones: the GREPCO
experience. Hepatology 1995;21:655-60.
- 19. Jose F.Patino, G.A. Quintero. Asymptomatic
cholelithiasis revisited.World J Surg 1998;22:1119-24.
- 20. Thistle JL, Cleary PA, Lachin JM, Tyor MP, Hersh T.
The natural history of cholelithiasis; The national
cooperative gallstone study. Ann Intern Med
1984;101:171-5.
- 21. Ransohoff DF, Gracie WA, Wolfenson LB, Neuhauser
D. Prophylactic cholecystectomy or expectant
management for silent gallstones. A decision analysis
to assess survival. Ann Intern Med 1983;99(2):199-
204.
- 22. Velanovich V, Morton JM, McDonald M, Orlando R,
Maupin G, Traverso LW. Analysis of the SAGES
outcomes initiative cholecystectomy registry. Surgical
Endoscopy 2006;20(1):43-50.
- 23. Schwesinger WH, Diehl AK. Changing indications for
laparoscopic cholecystectomy, stones without
symptoms and symptoms without stones. Surg Clin
NorthAm 1996;76(3):493-504.
- 24. Lo CM, Lai EC, Fan ST, Liu CL, Wong J.Laparoscopic
cholecystectomy for acute cholecystitis in the elderly.
World J Surg 1996;20:983-7.
- 25. Lujan JA, Parrilla P, Robles R, Torralba JA, Garcia
Ayllon J, Liron R, Sanchez-Bueno F. Laparoscopic
cholecystectomy in the treatment of acute cholecystitis.
JAm Coll Surg 1995;181 (1):75-7.
- 26. Coelho JC, Vizzoto AO, Salvalaggio PR, Tolazzi AR.
Laparoscopic cholecystectomy to treat patients with
asymptomatic gallstones. Dig Surg 2000;17:344-7.
- 27. Hiroshi Y, Masakatsu K, Takashi I, Toshiyuki K,
Takushi M. Laparoscopic cholecystectomy for
asymptomatic cholelithiasis. Digestive Endoscopy
2003;15:190-5.
- 28. Eypasch E, Williams JI, Wood-Dauphinee S, Ure BM,
Schmulling C, Neugebauer E, Troidl H.
Gastrointestinal quality of life index: Development,
validation and application of a new instrument. Br J
Surg 1995; 82(2): 216-22.
- 29. Finan KR, Leeth RR, Whitley BM, Klapow JC, Hawn
MT. Improvement in gastrointestinal symptoms and
quality of life after cholecystectomy. Am J Surg
2006;192:196-202.