ALT SOLUNUM YOLU ENFEKSİYONLARI VE ÜST ÜRİNER SİSTEM ENFEKSİYONLARINDA TROMBOSİTOZ ORANLARI VE DEĞERLENDİRİLMESİ
AMAÇ:Alt solunum yolu enfeksiyonları ve üst üriner sistem enfeksiyonlarında trombositoz oranlarınınçıkarılması ve değerlendirilmesi amaçlanmıştır.GEREÇ VE YÖNTEM:Bu çalışmada “GATA Haydarpaşa Eğitim Hastanesi Çocuk Kliniği'nde” 1 Ocak 20061 Ocak 2009 yılları arasında yatırılarak tedavi verilen 20 alt solunum yolu enfeksiyonu (ASYE) ve 22 üst ürinersistem enfeksiyonu (ÜÜSE) tanısı alan hastanın dosyaları retrospektif olarak incelendi. Reaktif trombositoz,genel olarak kabul gören trombosit sayısının 500.000/mm üzeri olması kabul edildi. İstatistiksel veriler SPSS13.0 ile değerlendirildi.BULGULAR:Çalışmamızda trombositoz tanı anında üst üriner sistem enfeksiyonlarında daha fazla bulundu(ASYE %25, ÜÜSE %36). Üst üriner sistem enfeksiyonlarında en sık üreyen mikroorganizma Escherichia coli(n:12 %54) olarak tespit edildi.SONUÇ:Çalışmamızda, alt solunum yolu enfeksiyonu ve üst üriner sistem enfeksiyonunda tanı anında görülenreaktif trombositoz ile hastalık şiddeti karşılaştırılmış, arasında istatistiksel olarak anlamlı bir ilişkibulunamamıştır
Evaluation of the Rate of Thrombocytosis in Lower Respiratory Tract and Upper Urinary System Infections
To evaluate the rates of thrombocytosis in lower respiratory tract (LRTI) and upper urinary system infections (UUSI). In this study, rates of thrombocytosis were evaluated in patients hospitalized and treated with the diagnosis of LRTI (n=20) or UUSI (n=22) in “GATA Haydarpasa Teaching Hospital, Department of Pediatrics” between 2006-2009, retrospectively. Reactive thrombocytosis is defined as the platelet count over 500.000/mm . Statistical analysis was performed by SPSS for Windows version 13.0. p≤0.05 was accepted as statistically significant. Thrombocytosis was found to be higher in the UUSI (%36) at the time of the diagnosis compared to the LRTI group (25%). The most common microorganism identified in the UUSI was Escherichia coli (n=12, 54%). There was no significant relationship between the reactive thrombocytosis observed at the time of the diagnosis and the severity of the disease in the LRTI and the UUSI
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- 1. Schafer AI. Thrombocytosis and thrombocytemia.
Blood Rev 2001;15:159-66.
- 2. Hollen CW, Henthorn J, Koziol JA, Burstein SA.
Elevated serum interleukin-6 levels in patients with
reactive thrombocytosis. Br J Haematol 1991;79:286-
90.
- 3. Haznedaroğlu IC, Ertenli I, Ozcebe OI, et al.
Megakaryocyte- related interleukins in reactive
thrombocytosis versus autonomous thrombocthemia.
Acta Haematol 1996;95:107-11.
- 4. Dan K, Gomi S, Inokuchi K, et al. Effects of
interleukin-1 and tumor necrosis factor on
megakaryocytopoiesis: mechanism of reactive
thrombocytosis.Acta Haematol 1995;93:67-72.
- 5. Dame C, Sutor AH. Primary and secondary
thrombocytosis in childhood. Br J Haematol
2005;129:165-77.
- 6. Taksin AL, Couedic JP, Dusanter-Fourt I, et al.
Autonomous megakaryocyte growth in essential
thrombocythemia and idiopathic myelofibrosis is not
related to a c-mpl mutation or to an autocrine
stimulation by Mpl-L. Blood 1999;93:125-39.
- 7. Schafer AI. Thrombocytosis. N Engl J Med
2004;350:1211-9.
- 8. Eliot MA, Pardanani A, Lasho TL, Schwager SM,
Tefferi A. Thrombosis in myelofibrosis: prior
thrombosis is the only predictive factor and most
venous events are provoked. Haematologica
2010;95:1788-91.
- 9. Heits F, Stahl M, Ludwig D, Stange EF, Jelkmann W.
Elevated serum thrombopoietin and interleukin-6
concentrations in thrombocytosis associated with
inflammatory bowel disease. J Interferon Cytokine Res
1999;19:757-60.
- 10. Vora AJ, Lilleyman JS. Secondary thrombocytosis.
Arch Dis Child 1993;68:88-90.
- 11. Chan KW, Kaikov Y, Wadsworth LD. Thrombocytosis
in childhood: a survey of 94 patients. Pediatrics
1989;84:1064-7.
- 12. Yohannan MD, Higgy KE, al-Mashhadani SA,
Santhosh-Kumar CR. Thrombocytosis. Etiologic
analysis of 663 patients. Clin Pediatr 1994;33:340-3.
- 13. Catal F,Bavbek N, Bayrak O, et al. Platelet paramaters
in children with upper urinary tract infection: Is there a
specific response? Renal Failure 2008;30:377-81.
- 14. Garoufi A, Voutsioti K, Tsapra H, Karpathios T, Zeis
PM. Reactive thrombocytosis in children with upper
urinary tract infections.Acta Peadiatr 2001;90:448-9.