Cilt Beyazlatıcılara Genel Bakış

Dünyada cilt beyazlatma uygulamalarına talebin arttığı ve gerek doğal cilt renginin açılması gerekse çeşitli nedenlerle oluşan lekelerin giderilmesi amacıyla sistemik veya lokal etkili cilt beyazlatıcı ürünlerin kullanıldığı bilinmektedir. Deri renginde koyulaşma olan hiperpigmentasyonun güneş/ UV ışınlarına ve çeşitli kimyasal maddelere (ilaç, kozmetik vd.) maruz kalma ya da bazı hastalıklar nedeniyle meydana gelebildiği ayrıca mekanik travma, kimyasal soyma, lazer uygulamaları, akne veya bazı deri hastalıklarına cevaben oluşabildiği bilinmektedir. Hiperpigmentasyona bağlı cilt lekelerinin giderilmesinde nedeninin incelenmesinden sonra depigmentasyona yönelik ürün kullanımı, kimyasal soyma, kriyoskopi, lazer uygulaması veya cerrahi işlem uygulanabilmektedir. Depigmentasyona yönelik aktif bileşikler etki mekanizmalarına göre melanin sentezi öncesi, melanin sentezi sırasında ve melanin sentezi sonrasında etkili olanlar ile diğerleri olarak gruplandırılabilmektedir. Cilt beyazlatıcı aktif bileşenler ve formülasyonlar yapısal olarak incelendiğinde biyoteknolojik, botanik veya kimyasal kökenli bileşiklerin farmasötik şekil olarak deriye uygulanan preparatlar (krem, emülsiyon, jel, çözelti vb.) veya oral olarak alınan preparatlar (kapsül, tablet vd.) halinde uygulandığı görülmektedir. Bu bileşiklerin son yıllarda nanoteknoloji ve modern farmasötik taşıyıcı sistemlerden (nanoemülsiyon, nanoküre, nanokapsül, nanozom, katı lipit nanopartikül, nano yapılı lipit taşıyıcılar, niozom, etozom, lipozom, vd.) yararlanılarak hazırlandığı uluslararası yasal farklılıklar doğrultusunda ilaç, kozmetik veya gıda kategorisinde piyasaya sunulduğu görülmektedir.

Skin Whiteners An Overview

It has known that the demand for skin whitening application has increased in the world and use of systemic or locally effective skin whitening products, whether for lightening natural skin color or to remove dark spots caused by a variety of reasons. Hyperpigmentation which is darkening of skin color known that can be caused by exposure to sun/UV rays, various chemicals (drug, cosmetics, etc.), certain diseases, mechanical trauma, chemical peels, laser applications, and in response to acne or some skin diseases. After examining the reasons of hyperpigmentation, the following may be applied for the removal; the use of products intended for depigmentation, chemical peelings, cryoscopy, laser treatment or surgery. The active compounds for depigmentation can be grouped according to their mechanism of action as the ones effective during premelanin synthesis, during melanin synthesis, after the melanin synthesis and others. When the skin whitening active ingredients and formulations examined structurally it is seen that they are appiled as pharmaceutical forms of dermal preparations (creams, emulsions, gels, solutions, etc.) or oral preparations (capsule, tablet, etc.) of biotechnological, botanical or chemical originated actives. In recent years it is seen that these actives are prepared by utilising nanotechnology and pharmaceutical carriers (nanoemulsions, nanospheres, nanocapsules, nanosomes, solid lipid nanoparticles, nanostructured lipid carriers, niosomes, ethozomes, liposomes, etc.) and launched to the market in the category of drug, cosmetic or food in accordance with the scope of the international legal differences.

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