Analgesic and anti-inflammatory activity of crude leaf and bark extract of Lantana Camara

The purpose of present study was to investigate the analgesic and anti-inflammatory activity of Lantana camara (Verbenaceae) leaf and bark extract. The methanol extract of Lantana camara (MELC) was screened for possible analgesic activity by acetic acid, hot plate and anti-inflammatory activity by carrageenan and histamine induced paw edema. The result showed that, MELC (100 mg/kg and 200 mg/kg) leaf and bark possessed significant (P

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Sawadogo WR, Boly R, Lompo M, Some N. Anti-inflammatory, analgesic and antipyretic activities of Dicliptera verticillata. Int J Pharmacol 2006; 2: 435-8.

Trigonella foenum-graecum (seed) extract. Acta Pol Pharm 2008; 65: 473-6.

Vyas S, Agrawal PR, Solanki P, Trivedi P. Analgesic and antiinflammatory activities of

Adedapo AA, Sofidiya MO, Masika PJ, Afolayan AJ. Antiinflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animals. Basic Clin Pharmacol Toxicol 2008;103:397-400.

Guideline on acute oral toxicity. Organization for Economic Cooperation and Development (OECD), Paris, France. 2005.

Nayak BS, Raju SS, Ramsubhag A. Investigation of wound healing activity of Lantana camara L. in Sprague dawley rats using a burn wound model. Int J Appl Res Nat Prod 2008;1:159.

Rakh MS, Khedkar AN, Aghav NN, Chaudhari SR. Antiallergic and analgesic activity of Momordica dioica roxb. wild fruit seed. Asian Trop J Biomed 2012; 2: 192-6.

Wang Y, Chen Y, Xu H, Luo H, Jiang R. Analgesic effect of glycoproteins from Panax ginseng root in mice. J Ethnopharmacol 2013;148: 946-50.

Nahar L, Zahan R, Tareq M, Haque A, Alam Z, Mosaddik A. Antioxidant, analgesic and CNS depressant activity of Synedrella nodiflora. Pharmacogn J 2012;4:29-36.

Pavao Desouza GF, Zarpelon AC, Tedeschi GC, Mizokami SS, Sanson JS, Cunha TM, Ferreira SH, Cunha FQ, Casagrande R, Verri Jr WA.Acetic and phenyl p-benzoquinone induced overt pain like behavior depends on spinal activation of MAP kinases, PI3K and microglia in mice. Pharmacol Biochem Behav 2012;101: 320-8.

Silva VG, Silva RO, Damasceno SR, Carvalho NS, Prudêncio RS, Aragão KS,Guimarães MA, Campos SA, Véras LM, Godejohann M, Leite JR, Barbosa AL, Medeiros JV.Antiinflammatory and antinociceptive activity of epiisopiloturine, an imidazole alkaloid isolated from Pilocarpus microphyllus. J Nat Prod 2013; 76:1071-7.

AM, Cavada BS. Neutrophil-infltrated paw edema induced by mannose-binding Dioclea violacea lectin. Pharmacol Rep 2013; 65 :220-5.

de Alencar NM, Mota MR, Rodrigues NV, Martins JL, do Nascimento KS, Assreuy

Kumar S, Kumar V, Prakash OM. Pharmacognostic study and anti-inflammatory activity of Callistemon lanceolatus leaf. Asian Pacific J Trop Med 2011; 1:177-81.

Valiollah H, Hossein S, Mohsen M, Ahmad M, Ardeshir T. Effect of fluvoxamine on carrageenan-induced paw edema in rats evaluation of action sites. Iran J Pharm Res 2011;10:611-8.

OECD. Guidelines for testing of chemicals, Acute oral toxicity -acute toxic class method. Paris: OECD; 2001. [Online] Available from: http://iccvam.niehs.nih.gov/SuppDocs/ FedDocs/ OECD/OECD_GL423.pdf.

Pharmacognosy, 1st edition. Editors : Kokate CK, Purohit AP, Gokhle SB. Nirali Prakashan, Pune. 1990, pp 178–181

Bairagi SM, Aher AA, Nema N, Pathan IB. Evaluation of AntiDiarrhoeal activity of the leaves extract of Ficus Microcarpa L. (Moracea). Marmara Pharm J 2014;18: 135-8.

Trease GE, Evans WC. Text book of Pharmacognosy, 15th edition. Bailliere Tindall, London. 2006, pp. 135–139

Adedapo AA, Sofidiya MO, Masika PJ, Afolayan AJ. Antiinflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animals. Basic Clin Pharmacol Toxicol 2008;103:397-400.

Raghu C, Ashok G, Suresh B. In vitro cytotoxic activity of Lantana camara Linn. Indian J Pharmacol 2004; 36: 94-5.

Noble D, Lane SJ, Sidebottom PJ, Lynn SM. Isolation of translactone-containing triterpenes with thrombin inhibitory activities from the leaves of Lantana camara. J Nat Prod 1998; 61: 1328-31.

Misra LN, Dixit AK, Sharma RP. High concentration of hepatoprotective oleanolic acid and its derivatives in Lantana camara roots. Planta Medica 1997; 63:582.

Garg SK, Shah MA, Garg KM. Antilymphocytic and immunosuppressive effects of Lantana camara leaves in rats. Indian J Exp Biol 1997;35: 1315-8.

Chellaiah M, Muniappan A, Nagappan R, Savarimuthu I. Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, India. J Ethnobiol Ethnomed 2006; 2: 43.

Hernández T, Canales M, Avila JG, Duran A, Caballero J, Romo de Vivar A, Lira R. Ethnobotany and antibacterial activity of some plants used in traditional medicine of Zapotitlán de las Salinas, Puebla (México). J Ethnopharmacol 2003; 88: 181-8.

Afolayan AJ, Meyer JJM. The antimicrobial activity of 3, 5, 7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens. J Ethnopharmacol 1997; 57: 177-81.

Abou-Karam M, Shier WTA. Simplified plaque reduction assay for antiviral agents from plants. Demonstration of frequent occurrence of antiviral activity in higher plants. J Nat Prod 1990; 53: 340-4.

Ramchandran S, Rajini Kanth B,Rajsekaran A, Manisenthil Kumar KT. Evaluation of anti- inflammatory and analgesic potential of methanol extract of Tectona grandis flowers. Asian Pac J Trop Biomed 2011; 155-8.

Farshchi A, Ghiasi G, Malek Khatabi P, Farzaee H, Niayes A. Antinociceptive effect of promethzine in mice. Iran J Basic Med Sci 2009;12:140-5.

Domaj MI, Glassco W, Aceto MD, Martin BR. Antinociceptive and pharmacological effects of metanicotina, a selective nicotine agonist. J Pharmacol Exp Ther 1999; 291: 390-8.

Shukla S, Mehta P, Vyas SP, Shukla S, Bajpai VK. Studies on anti-inflammatory, antipyretic and analgesic properties of Caesalpinia bonducella F. seed oil in experimental animal models. Food Chem Toxicol 2010; 48:61-4.
Marmara Pharmaceutical Journal-Cover
  • ISSN: 1309-0801
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1985
  • Yayıncı: Marmara Üniversitesi
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