Oytun Ayşe BAYRAK, Hande TÜRKER, Ahmet YILMAZ, Musa Kazım ONAR

Severe perıpheral neuropathy secondary to vincristın therapy

Herediter nöropatisi olan hastaların vinkristin nörotoksisitesi için yüksek risk taşıdığı bilinmektedir. Burada, daha önceden bilinen nöropatisi olmayan ve düşük doz vinkristin tedavisi sonrası düşük ayak gelişen iki olgu literatür eşliğinde sunulmuştur. Olguların rapor edilmesinin amacı tedavi öncesi ayrıntılı nörolojik muayenenin ve öyküde herediter nöropati varlığının araştırılmasının önemini vurgulamaktır

Vinkristin tedavisine bağlı gelişen ağır periferik nöropati

Patients with hereditary neuropathy being at high risk of severe vincristin neurotoxicity are well known. Here, along with the review of the literature, we described two patients with unrecognized hereditary neuropathy who developed foot drop following low dose vincristin therapy. With this report we wanted to emphasize the importance of detailed neurologic examination and history taking before initiating therapy.

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