Hüsnü TOKGÖZ, Özlem TÜRKSOY, Bülent EROL

Possible serum markers for renal transitional cell carcinoma: Report of a case with the review of literature

Üriner sistemin üst bölümünün ürotelyal tümörü, relatif olarak nadir görülen malignitelerden biridir. Prostat ve testis kanserlerine özgü serum belirteçleri bilinmesine rağmen, renal ve ürotelyal tümörler için spesifik belirteçlerin tanımlanmasına ihtiyaç vardır. Bu makalede, yüksek preoperatif serum düzeyine sahip Karsinoembryonik antijen (CEA) ve Eritrosit sedimentasyon hızına (ESR) sahip olgu sunulacaktır. Preoperatif metastazı olmayan hastaya uygulanan radikal nefroüreterektomi operasyonu sonrası, histolojik tanı yüksek grade’li renal pelvis ürotelyal karsinomu olarak rapor edilmiştir. Cerrahi sınırlar negatif olup serum CEA ve ESR düzeyinde postoperatif erken dönemde tamamen düzelme görülmüştür.

Renal transizyonel hücreli karsinom için olası serum belirteçleri: Literatürün gözden geçirilmesi ile birlikte bir olgunun sunumu

Urothelial tumors of the upper urinary tract are relatively rare malignancies of urinary system. Despite the presence of specific serum parameters for prostate and testicular cancer, new markers need to be identified for renal and urothelial cancers. We report a case of huge renal pelvis tumor with high serum levels of carcinoembryonic antigen (CEA) and erythrocyte sedimentation rate (ESR). No distant metastasis was evident preoperatively. Radical nephroureterectomy was performed and the tumor was histologically diagnosed as high grade urothelial carcinoma of the renal pelvis. Surgical margins were negative and marked decrease in serum level of CEA and normalization of ESR, were noticed immediately after surgery.

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