Alper ÇELİK, SUAT KUTUN, Turgay FEN, Gülay BİLİR, Akın ÖNDER, Abdullah ÇETİN

Lenfoma nedeniyle uygulanan radyoterapi sonrası sekonder maligniteler - Olgu sunumu

Bu olgu sunumunda Hodgkin lenfoma tanısıyla baş-boyun bölgesine radyoterapi uygulanmasını takiben ortaya çıkan akciğer ve çoklu cilt kanserleri tespit edilen bir olgu sunulmuştur. Elli yaşında, Evre IA Hodgkin lenfoma nedeniyle mantle alanına radyoterapi verilen erkek hastada, 6 yıl sonra burun üzerinde bazal hücreli karsinom, sağ kulak üzerinde invaziv epidermoid karsinom ve sol infraorbital bölgede in-situ epidermoid karsinom tespit edildi. Cerrahi tedavi sonrası sağ aurikuler alana ve sol infraorbital sahaya lateral cerrahi sınırın yakın olması ve hastanın re-eksizyonu kabul etmemesi nedeniyle radyoterapi verilen olgu bir yıl sonra nefes darlığı şikayeti ile başvurdu. Sağ akciğer üst ve orta zonları tutan kitle tespit edilen olgunun bronkoskobik biyopsi sonucu Epidermoid karsinom olarak rapor edildi. Vena cava superior sendromu tespit edilen hastaya tekrar radyoterapi ve medikal tedavi uygulandı. Genel durumu giderek bozulan hasta 15 gün sonra öldü.

Secondary malignancies after lymphoma treated by radiotherapy - Case report

We hereby describe a case of Hodgkin lymphoma treated with radiotherapy to head and neck region, who further developed lung and multiple skin cancers. A 50-year-old male patient with stage IA Hodgkin lymphoma was treated with radiotherapy to mantle zone. Six years later we detected basal cell carcinoma on his nose, invasive epidermoid carcinoma on his right ear, and in-situ epidermoid carcinoma on left infraorbital area. After surgical removal, radiotherapy was applied to right auricular area and left infraorbital area due to close lateral margin and the patient�s refusal for re-excision. One year later he admitted with dyspnea. We detected a mass involving the upper and middle zones of his right lung, and bronchoscopic biopsy revealed epidermoid carcinoma. Vena cava superior syndrome was established, and he was re-treated with radiotherapy and medical treatment. His medical condition deteriorated, and 15 days later he died.

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