Koilosit oluşumuna insan papilloma virüs proteinleri ile yaklaşım

Koilos Yunanca “boşluk” anlamına gelmektedir. Koilosit ise insan papilloma virüsün (HPV) karakteristik özelliği olarak karşımıza çıkan ve çekirdeği etrafında büyük boşluk içeren hücredir. HPV, enfekte ettiği hücre ve dokuların sitoplazma ve çekirdeklerinde kendi yapısal proteinleri aracılığıyla çeşitli değişikliklere neden olmaktadır. Virüsün yapısal proteinleri ve tümör baskılayıcı genler bu hücresel değişikliklerden koilos oluşumunda rol oynamaktadır. Koilositlerin serviko-vajinal yaymalarda görülmesi, HPV varlığı, tiplendirilmesi ve bu virüs varlığıyla oluşabilecek servikal kanser vakalarının erken teşhisi açısından oldukça önemlidir. Buna bağlı olarak derleme yazısında koilosit oluşum mekanizması insan papilloma virüs proteinleri ve tümör baskılayıcı genler aracılığıyla açıklanmaya çalışılmıştır.

Approach to koilocytosis mechanism by hpv proteins

Koilos means “hollow” in Greek. Koilocyte is a cell with a big perinuclear halo, characteristic of the human papilloma virus (HPV). HPV causes various changes through its structural proteins in the cytoplasms and nuclei of the cells and tissues it infects. Among these cellular changes, koilos formation is influenced by the structural proteins of the virus and tumour suppressor genes. The koilocytes observed in cervico-vaginal smears are considerably important for observing the presence of HPV, its typification, and early diagnosis of cervical cancer cases due to this virus. Therefore, this research attempts to explain the koilocyte formation mechanism by human papillomavirus proteins and tumour suppressor genes.

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