Yılmaz TABEL, İLKE MUNGAN AKIN, Serdal GÜNGÖR, Cemşit KARAKURT, Ünsal ÖZGEN

Reversible posterior leucoencephalopathy in an 11 year-old male child with lupus nephritis

Sistemik lupus eritematozus değişik klinik bulgularla kendini gösterebilen, kronik inflamatuar bir hastalıktır. Çocuklardaki organ tutulumları erişkin ile benzerlik göstermektedir.Sistemik lupus eritematozuslu hastalarda santral sinir sistemi tutulumunun erken tanınması ve önlenmesi uzun dönem nörolojik komplikasyonlar ve ölüm açısından çok önemlidir. Bu yazıda; kliniğimizde takip ettiğimiz 11 yaşında, sistemik lupus eritematozusun çok nadir bir tutulum ve komplikasyonunu gösteren erkek hastayı sunmak istedik. Hastada siklofosfamidin ilk dozundan sonra reversibl posterior liökoensefalopati gelişti.Literatürde bu ilacın bu komplikasyonun gelişimindeki rolü açık olmadığından, ilacın kesilmesine gerek görülmedi ve buna rağmen hasta tamamen düzeldi.

Lupus nefritli 11 yaşında erkek çocukta geri dönüşümlü posterior lökoensefalopati

Systemic lupus erythematosus is a chronic inflammatory disease characterized by highly diverse clinical manifestations. The major organ system involvements in childhood systemic lupus erythematosus are similar to those found in adults. Recognizing and reversing secondary causes of central nervous system abnormalities in patients with systemic lupus erythematosus are essential for preventing long term neurologic disability or death. In this manuscript, we present an 11 year old male followed up in our clinic, who had the very rare involvement and complications of systemic lupus erythematosus in childhood. He developed a reversible posterior leucoencephalopathy after the first dose of cyclophosphamide, but cyclophosphamide therapy was not stopped as there is no clear evidence in the literature related to the role of this drug in reversible posterior leucoencephalopathy. The patient has now recovered.

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