Kadriye ERDOGAN, Nazlı Tunca SANLIER, Emine UTLU OZEN, Serdar DILBAZ, Inci KAHYAOGLU, Yaprak Engin USTUN

Investigating the impact of endometrial compaction on clinical pregnancy rate in artificial frozen-thawed embryo transfer cycles

Anahtar Kelimeler:

Endometrial compaction, Artificial frozen embryo transfer cycles, Clinical pregnancy rate, Day of embryo transfer

Investigating the impact of endometrial compaction on clinical pregnancy rate in artificial frozen-thawed embryo transfer cycles

Objective: The aim of our study was to evaluate sonographic endometrial thickness succeeding the estrogen-only stage and on the day when embryo transfer (ET) occurred in artificial frozen embryo transfer (FET) cycles to delve into the effect of endometrial compaction (EC) on clinical pregnancy rate (CPR). Patients and Methods: In the first group endometrial thickness diminished when ET occurred when compared to the end of the estrogen-only phase (n:37). Endometrial thickness increased/did not alter for the second group (n:70). Demographic characteristics were recorded and the following were studied: in vitro fertilization (IVF) treatment indications, hormone levels, total antral follicle count, duration of infertility, embryo quality, embryo-fundus distance, endometrial thickness at the end of estrogen-only phase and on ET day, luteal support, CPR. Results: No significant difference occurred in CPRs (n:107). ET, on day 5 was higher in the first group (p

Keywords:

Endometrial compaction, Artificial frozen embryo transfer cycles, Clinical pregnancy rate, Day of embryo transfer,

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Bergh PA, Navot D. The impact of embryonic development and endometrial maturity on the timing of implantation. Fertil Steril 1992;58:537-42. doi: 10.1016/s0015- 0282(16)55259-5.
Kovacs P, Matyas S, Boda K, Kaali SG. The effect of endometrial thickness on IVF/ICSI outcome. Hum Reprod 2003;18:2337- 41. doi: 10.1093/humrep/deg461. PMID: 14585884.
Zhao J, Zhang Q, Wang Y, Li Y. Endometrial pattern, thickness and growth in predicting pregnancy outcome following 3319 IVF cycle. Reprod BioMed Online 2014;29:291-8. doi: 10.1016/j.rbmo.2014.05.011.
Liu KE, Hartman M, Hartman A, Luo ZC, Mahutte N. The impact of a thin endometrial lining on fresh and frozenthaw IVF outcomes: an analysis of over 40 000 embryo transfers. Hum Reprod 2018;33:1883-8. doi: 10.1093/humrep/ dey281.
El-Toukhy T, Coomarasamy A, Khairy M, et al.. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil Steril 2008;89:832-9. doi: 10.1016/j.fertnstert.2007.04.031.
Barker MA, Boehnlein LM, Kovacs P, Lindheim SR. Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles. J Assist Reprod Genet 2009;26:243-9. doi: 10.1007/s10815.009.9312-z.
Haas J, Smith R, Zilberberg E, et al. Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers. Fertil Steril 2019;112:503-9. doi: 10.1016/j. fertnstert.2019.05.001.
Bu Z, Yang X, Song L, Kang B, Sun Y. The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst. Reprod Biol Endocrinol 2019;17:99. doi: 10.1186/s12958.019.0545-0.
Zilberberg E, Smith R, Nayot D, et al. Endometrial compaction before frozen euploid embryo transfer improves ongoing pregnancy rates. Fertil Steril 2020;113:990-5. doi: 10.1016/j. fertnstert.2019.12.030.
Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 2011;26:1270-83. doi: 10.1093/ humrep/der037.
Bourdon M, Santulli P, Maignien C, et al. The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: A retrospective matched cohort study. PLoS One 2018;13:e0194800. doi: 10.1371/ journal.pone.0194800.
Ye J, Zhang J, Gao H, et al. effect of endometrial thickness change in response to progesterone administration on pregnancy outcomes in frozen-thawed embryo transfer: analysis of 4465 cycles. Front Endocrinol (Lausanne) 2020;11:546232. doi: 10.3389/fendo.2020.546232.
Jin Z, Li J, Yang E, et al. Effect of endometrial thickness changes on clinical pregnancy rates after progesterone administration in a single frozen-thawed euploid blastocyst transfer cycle using natural cycles with luteal support for PGT-SR – and PGT-M-assisted reproduction: a retrospective cohort study. Reprod Biol Endocrinol 2021;19:154. doi: 10.1186/ s12958.021.00841-x.
Kaye L, Rasouli MA, Liu A, et al. The change in endometrial thickness following progesterone exposure correlates with in vitro fertilization outcome after transfer of vitrified-warmed blastocysts. J Assist Reprod Genet 2021;38:2947-53. doi: 10.1007/s10815.021.02327-6. Epub 2021 Sep 28.
Olgan S, Dirican EK, Sakinci M, et al. Endometrial compaction does not predict the reproductive outcome after vitrified-warmed embryo transfer: a prospective cohort study. Reprod Biomed Online 2022;45:81-7. doi: 10.1016/j. rbmo.2022.02.025.
Mayer RB, Ebner T, Weiss C, et al. The role of endometrial volume and endometrial and subendometrial vascularization parameters in a frozen embryo transfer cycle. Reprod Sci 2019 Jul;26:1013-1018. doi: 10.1177/193.371.9118804421. Epub 2018 Nov 12. PMID: 30419800.
Raga F, Bonilla-Musoles F, Casan EM, Klein O, Bonilla F. Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity. Hum Reprod 1999;14:2851-4. doi: 10.1093/ humrep/14.11.2851.
Fleischer AC, Pittaway DE, Beard LA, et al. Sonographic depiction of endometrial changes occurring with ovulation induction. J Ultrasound Med 1984;3:341-6. doi: 10.7863/ jum.1984.3.8.341. PMID: 6434749.
Usadi RS, Groll JM, Lessey BA, et al. Endometrial development and function in experimentally induced luteal phase deficiency. J Clin Endocrinol Metab 2008 ;93:4058-64. doi: 10.1210/jc.2008-0460..
Yoo JY, Kim TH, Fazleabas AT, et al. KRAS activation and over-expression of SIRT1/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance. Sci Rep 2017;7:6765. doi: 10.1038/s41598.017.04577-w.
Hu M, Li J, Zhang Y, et al. Endometrial progesterone receptor isoforms in women with polycystic ovary syndrome. Am J Transl Res 2018 ;10:2696-2705.