Hayrullah ALP, HASİBE ARTAÇ, Esma ALP, İsmail REİSLİ

Acute infantile hemorrhagic edema: A clinical perspective (report of seven cases)

Akut infantil hemorajik ödem (AIHE) nadir görülen bir kutanöz lökositoklastik vaskülit olup geniş purpurik deri döküntüleri, akral ödem ve ateş ile karakterizedir. Korkutucu başlangıcı olmasına rağmen haftalar içinde sekel bırakmadan spontan iyileşme görülür. AIHE'in etyolojisi belli değildir ve spesifik bir tedavisi yoktur. Bu makalede, hastanemize 2003-2006 tarihleri arasında başvuran ve AIHE tanısı konan yedi vakayı sunduk. Biz antihistminik tedavinin hastalığın seyri üstündeki etkisini araştırdık ve AIHE'in diğer purpurik hastalıklardan ayırıcı özelliklerini gözden geçirdik.

Akut infantil hemorajik ödem: Klinik bir bakış (yedi vakanın sunumu)

Acute infantile hemorrhagic edema (AIHE) is an uncommon cutaneous leukocytoclastic vasculitis characterized by large purpuric skin lesions, acral edema and fever. In spite of violent onset, spontaneous recovery without any sequelaes occurs within a few weeks. The causes of AIHE are unknown and there is no specific treatment. In this article, we have presented seven cases with AIHE admitted to our hospital between 2003-2006. We evaluated the effect of antihistaminic treatment on the course of the disease and we also reviewed the features of AIHE distinguishable from other purpuric diseases.

PDF

___

1) Legrain V, Lejean S, Taieb A, Guillard JM, Battin J, Maleville J. Infantile acute hemorrhagic edema of the skin: study of ten cases. J Am Acad Dermatol 1991; 24: 17-22.
2) Ince E, Mumcu Y, Suskan E, Yalcinkaya F, Tümer N, Cin S. Infantile acute hemorrhagic edema: A variant of leukocytoclastic vasculitis. Pediatr Dermatol 1995; 12: 224-227.
3) Odom RB, James WD, Berger TG. Cutaneous vascular diseases. In: Odom RB, James WD, Berger TG, eds. Andrews Diseases of the Skin, Clinical Dermatology, 9th ed. Philadelphia: W. B. Saunders; 2000: 1035-1036.
4) Caksen H, Odabas D, Kosem M, et al.Report of eight infants with acute infantile hemorrhagic edema and review of the literature. J Dermatol 2002; 29: 290-295.
5) Saraclar Y, Tinaztepe K, Adalioglu G, Tuncer A. Acute hemorrhagic edema of infancy (AHEI) - a variant of Henoch-Schönlein purpura or a distinct clinical entity? J Allergy Clin Immunol 1990; 86: 473-483.
6) Bozaykut A, Pulat-Seren L, Ozahi-Ipek I, Vardar-Tuncel G. Acute infantile hemorrhagic edema as a differential diagnosis of purpura: Report of three patients. Çocuk Sağlığı ve Hastalıkları Dergisi 2005; 48: 147-150.
7) Snow IM. Purpura, urticaria and angioneurotic edema of the hands and feet in a nursing baby. JAMA. 1913;61:18-19.
8) Paradisi M, Annessi G, Corrado A. Infantile acute hemorrhagic edema of the skin. Cutis 2001; 68:127-129.
9) Jeannoel P, Fabre M, Payen C, Bost M. Acute hemorrhagic edema in infants: Role of adenoviruses? Apropos of a case. J Am Acad Dermatol. 1997; 37: 673-705.
10) Di Lernia V, Lombardi M, Lo Scocco G. Infantile acute hemorrhagic edema and ratovirus infection. Pediatr Dermatol 2004; 21: 548-550.
11) Morrison RR, Saulsbury FT. Acute hemorrhagic edema of infancy associated with pneumococcal bacteremia. Pediatr Infect Dis J 1999; 18: 832-833.
12) Millard T, Haris A, MacDonald D. Acute infantile hemorrhagic oedema. J Am Acad Dermatol 1999; 41: 837-839.
13) Taieb A, Legrain V. Acute hemorrhagic oedema of the skin in infancy. In: Harper J, Oranje A, Prose N, eds. Textbook of Pediatric Dermatology. Volume 2. USA: Philadelphia, Blackwell Science Ltd : 2002: 1569-1573.
14) Soter NA. Cutaneous necrotizing venulitis. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, eds. Fitzpatrick's Dermatology in General Medicine, 6th ed. Volume 2. USA: Philadelphia, The McGraw-Hill Companies:2003: 1731.
15) Parlak AH, Kavak A, Alper M, Özyurek H, Kocabay K. Acute infantile hemorrhagic edema: A case report. Çocuk Sağlığı ve Hastalıkları Dergisi 2002; 45: 326-329.
16) Di Lernia V, Ricci C. Skin manifestations with Rotavirus infections. Int J Dermatol 2006; 45: 759-761.
17) Weston WL, Orchard D. Vascular reactions. In: Schachner AL, Hansen CR, eds. Pediatric Dermatology, 3rd ed. Spain: Elsevier Limited: 2003: 824.
18) Taieb A, Legrain V. Acute hemorrhagic oedema of the skin in infancy. In: Harper J, Oranje A, Prose N, eds. Textbook of Pediatric Dermatology. Volume 2. USA: Blackwell Science Ltd : 2002: 1569-1573.
19) Soter NA. Cutaneous necrotizing venulitis. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, eds. Fitzpatrick's Dermatology in General Medicine, 6th ed. Volume 2. USA: The McGraw-Hill Companies:2003: 1731.