Melekber CAVUS OZKAN, Zeliha Leyla CINEL

Clinicopathological features of trichoblastomas and malignant variant: trichoblastic carcinoma

Objective: Trichoblastomas are rare benign tumors of the skin appendages with epithelial and mesenchymal components that exhibit differentiation to the follicular germinative epithelium and particularly to the follicular stroma of the skin. Our aim was to contribute to already limited literature data in order to gain more insights into the treatment and follow-up of patients with this condition. Methods and Materials: A total of 9 patients with trichoblastoma and 1 patient with malignant trichoblastoma were surgically treated between 2016 and 2020 at the Department of Plastic, Reconstructive and Aesthetic Surgery, School of Medicine, Marmara University. Results: Of the 10 patients with trichoblastoma, 5 were female and 5 were male, with a median age of 49 years. The smallest and largest lesion lenghts were 0.4 and 2 cm, respectively. Seven lesions had developed in the head and neck region, while 2 were in the trunk. One of our cases was a 45-year old female patient with a malignant trichoblastoma presented with a lesion in the right side of the lower lip. Conclusion: Trichoblastomas are rare tumors that affect both sexes equally and are seen most commonly in the head and neck region. Recurrence rates were found to be low when they were treated with negative surgical margins.

Keywords:

Skin Neoplasms Plastic Surgery, Histopathology,

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Headington JT. Differentiating neoplasms of hair germ. J Clin Pathol 1970;23:464-71. doi: 10.1136/jcp.23.6.464
Eshraghi B, Riazi-Esfahani H, Katoozpour R, Anvari P, Mortazavi M, Amoli FA. Trichoblastoma of the upper eyelid. J Ophthalmic Vis Res 2017;12 :219-21. doi: 10.4103/2008- 322X.205378.
Landolsi A, Khaled A, Bougacha L, et al. Giant trichoblastoma of the scalp. Tunis Med 2011;89:569-72.
Pina A, Sauthier P, Rahimi K. Vulvar trichoblastoma: case report and literature review. J Low Genit Tract Dis 2015;19:e10- 2. doi: 10.1097/LGT.000.000.0000000010.
Sathyaki DC, Riyas M, Roy MS, Swarup RJ, Raghu N. Pigmented trichoblastoma of nose: An unusual occurrence. J Clin Diagn Res 2017;11:Md09-md10. doi: 10.7860/ JCDR/2017/25798.10321.
Cakmak Genc G, Dursun A, Nagy N, Celikmakas A, Acuner B. Brooke-Spiegler Syndrome: Two patients from a Turkish family with multiple familial trichoepithelioma. Am J Dermatopathol 2019;41:778-80. doi: 10.1097/ DAD.000.000.0000001265.
Kutzner H KS, Kanitakis J,Kazakov DV, Schulz T, Singh R. Trichoblastoma In: Fred T. Bosman ESJ, Lakhani SR, Ohgaki H, editors. World Health Organization Classification of Tumours. 1. 4th ed. France: International Agency for Research on Cancer (IARC), 2018:201-2.
Morillo V, Manrique P, Vildósola S, Saiz A, Artola JL, Bilbao I. [Giant trichoblastoma]. Actas Dermosifiliogr 2006;97:467-9. doi: 10.1016/s0001-7310(06)73443-3.
Quist EE, DiMaio DJ. Melanotrichoblastoma: a rare pigmented variant of trichoblastoma. Cutis 2017;100:243-6.
Cho HK, Song JS, Kang WH, Ro BI. Pigmented trichoblastoma arising from the nevus sebaceous: a rare case in Korea. Ann Dermatol 2009;21:406-8. doi: 10.5021/ ad.2009.21.4.406.
Misago N, Narisawa Y. Tricholemmal carcinoma in continuity with trichoblastoma within nevus sebaceus. Am J Dermatopathol 2002;24:149-55. doi: 10.1097/00000.372.200204000-00008.
Kang TW, Kang H, Kim HO, Song KY, Park YM. Trichoblastoma in a child. Pediatr Dermatol 2009;26:476-7. doi: 10.1111/j.1525-1470.2009.00960.x.
Hua C, Velter C, Osio A, et al. Locally aggressive trichoblastic tumours (low-grade trichoblastic carcinomas): clinicopathological analysis and follow-up. Acta Derm Venereol 2018;98:126-7. doi: 10.2340/00015.555.2678.
Datiashvili RO, Izadi K, Centurion SA, Lambert WC, Scarpidis U. Malignant melanocytic trichoblastoma. Ann Plast Surg 2006;56:208-10. doi: 10.1097/01.sap.000.019.4243.85311.a1.
Lee JS, Kwon JH, Jung GS, et al. A giant trichoblastic carcinoma. Arch Craniofac Surg 2018;19:275-8. doi: 10.7181/ acfs.2018.02124.
Leblebici C, Özkur E, Gürel MS, Aksu AEK, Savaş S, Kiremitçi Ü. Rare case of trichogenic tumor: trichoblastic carcinoma. Istanb Med J 2016;17:32-4.
Lahbali O AM, Tbouda M, Bourhoum N, Znati K, Mahassini N. Rare location of a trichoblastic carcinoma: A case report. Austin J Dermatolog 2017;4:1075.
Laffay L, Depaepe L, d’Hombres A, Balme B, Thomas L, De Bari B. Histological features and treatment approach of trichoblastic carcinomas: from a case report to a review of the literature. Tumori 2012;98:46e-9e. doi: 10.1700/1088.11948.
Fusumae T, Tanese K, Takeuchi A, et al. High-grade trichoblastic carcinoma arising through malignant transformation of trichoblastoma: Immunohistochemical analysis and the expression of p53 and phosphorylated AKT. J Dermatol 2019;46:57-60. doi: 10.1111/1346-8138.14686.
Schulz T, Proske S, Hartschuh W, Kurzen H, Paul E, Wünsch PH. High-grade trichoblastic carcinoma arising in trichoblastoma: a rare adnexal neoplasm often showing metastatic spread. Am J Dermatopathol 2005;27:9-16. doi: 10.1097/01.dad.000.014.2240.93956.cb.
Kazakov DV, Banik M, Kacerovska D, Michal M. A cutaneous adnexal neoplasm with features of adamantinoid trichoblastoma (lymphadenoma) in the benign component and lymphoepithelial-like carcinoma in the malignant component: a possible case of malignant transformation of a rare trichoblastoma variant. Am J Dermatopathol 2011;33:729- 32. doi: 10.1097/DAD.0b013e31820b7b87.

ISSN: 1019-1941
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1988
Yayıncı: Marmara Üniversitesi

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