Ayfer AY EREN, Mehmet Fuat EREN

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Effect of molecular subtypes on radiotherapy response in patients with breast cancer brain metastasis

Objective: This study aimed to investigate survival and the response to radiotherapy (RT) among patients with molecular subtypes of breast cancer brain metastases. Patients and Methods: We retrospectively analyzed the data of 139 breast cancer patients with brain metastases treated with wholebrain radiotherapy (WBRT) or focal brain treatment (FBT) between 2006 and 2019. Overall survival (OS) and brain metastasis progression-free survival (BMPFS) were calculated from the first RT until death or the last follow-up. Survival analyses were performed using the Kaplan–Meier method. Prognostic factors were evaluated using the Cox proportional hazard model. Results: Twenty three (16.5%), 77 (55.4%), 14 (10.1%), and 25 (18%) patients were diagnosed with triple-negative, HER-2 (+), luminal-like A, and luminal-like B breast cancer, respectively. Of 139 patients, 66 (47.8%) underwent FBT, and 73 (52.5%) underwent WBRT. While the most preferred fraction was 10*300 Gy in WBRT, doses of 15-25 Gy in 1-5 fractions were preferred in local RT. We observed that age, Karnofsky performance scale (KPS) score, initial RT technique, extracranial disease, number of brain metastases impacted OS and BMPFS. Conclusion: Breast cancer brain metastasis is a different, complex, and challenging disease based on the molecular subtype of the tumor, despite various local treatments. Therefore, appropriate and tailored treatment approaches should be considered for the different molecular subtypes.
Keywords:

Breast cancer, Molecular subtype, Brain metastasis Radiotherapy, Survival outcomes,

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Marmara Medical Journal-Cover
  • ISSN: 1019-1941
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1988
  • Yayıncı: Marmara Üniversitesi
Arşiv
Sayıdaki Diğer Makaleler

Feriha ERCAN, Merve ACIKEL ELMAS

Ilknur ALSAN CETIN, Sıtkı Utku AKAY

Emrah KESKIN, Ozlem ELMAS, Havva Hande KESER SAHIN, Caghan TONGE, Ahmet GUNAYDIN

Hilal KURT SEZER, Deniz Sumeyye YORULMAZ, Sibel KUCUKOGLU

Firuz MAMMADOV, Sehnaz OLGUN YILDIZELI, Derya KOCAKAYA, Huseyin ARIKAN, Caner ÇINAR, Emel ERYUKSEL, Berrin CEYHAN

Ahmet TANYERI, Mehmet Burak CILDAG, Omer Faruk Kutsi KOSEOGLU

Cigdem OZPOLAT

Heval Can BILEK, Aydin DEVECI, Esra TANYEL

Ayfer AY EREN, Mehmet Fuat EREN

Fatıma Zehra SAFAK, Gokhan BICIM, Ayse Mine YILMAZ, Burak AKSU, A. Suha YALCIN