Emrah KESKIN, Ozlem ELMAS, Havva Hande KESER SAHIN, Caghan TONGE, Ahmet GUNAYDIN

3613

The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury

Objective: This study aimed to evaluate Annona muricata’s (AM) radioprotective effects on sciatic nerve injury due to ionising radiation (IR). Materials and Methods: Thirty-two adult female Wistar albino rats were separated into four equal groups; Control (C), Annona muricata leaf extracts (AME), radiation (RAD), radiation and AME (AME+RAD). In groups AME and AME+RAD, AME was administered at a dose of 300 mg/kg for the first day and 50 mg/every day for the following one week intraperitoneally. In RAD and AME+RAD, rats were exposed to a single dose of 20 Gray (Gy) IR to their right legs. All the subjects were sacrificed at the end of the first month. Oxidative stress biochemical parameters from blood samples were analysed. In addition, right sciatic nerves were extracted and histomorphology was evaluated. Results: Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME (p<0.01). Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of catalase (p<0.01), superoxide dismutase (p<0.01) and glutathione peroxidase (p<0.05) in the AME+RAD group compared to the RAD group were found to be statistically significant. Conclusion: Our study unveiled that AM could potentially enhance biochemical and histomorphological healing in the acute period on sciatic nerve injury due to IR.
Keywords:

Radiation, Sciatic nerve, Annona muricata, Neuroprotection, Oxidative stress,

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Marmara Medical Journal-Cover
  • ISSN: 1019-1941
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1988
  • Yayıncı: Marmara Üniversitesi
Arşiv
Sayıdaki Diğer Makaleler

Emrah KESKIN, Ozlem ELMAS, Havva Hande KESER SAHIN, Caghan TONGE, Ahmet GUNAYDIN

Heval Can BILEK, Aydin DEVECI, Esra TANYEL

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Nura Fitnat TOPBAS SELCUKI, Pinar YALCIN BAHAT, Cihan KAYA, Salim NESELIOGLU, Kubra BAGCI, Mustafa GOKSU, Meric KABAKCI, Ozcan EREL

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Feriha ERCAN, Merve ACIKEL ELMAS

Hande KAYMAKCALAN, Leyla YALCINKAYA, Emrah NIKEREL, Yalim YALCIN, Weilai DONG, Adife Gulhan ERCAN SENCICEK

Ali Cihat YILDIRIM, Sevil ALKAN CEVIKER, Sezgin ZEREN, Mehmet Fatih EKICI, Faik YAYLAK, Mustafa Cem ALGIN, Özlem ARIK

Aysegul UCUNCU KEFELI, Aysegul UNAL KARABEY, Umut Efe DOKURLAR, Berna TIRPANCI, Gulsah OZKAN, Aykut Oguz KONUK, Maksut Gorkem AKSU

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