Skolyoz Etiyopatojenezi: Kanıtlara Göre Değişen Paradigmalar

Omurganın yana olarak eğrilikleri olarak tanımlanan skolyoz, eski zamanlardan beri sebebi araştırılan ancak henüz kesin bulgular elde edilemeyen bir vücut deformitesidir. Klinik ve radyolojik olarak kolayca tanı konabilmesine rağmen, etyolojiyi aydınlatabilmek ve tedavi edebilmek o kadar kolay olamamaktadır. Etyoloji ile ilgili birçok teori öne sürülmüştür. Ancak zaman içinde moleküler seviyede bir takım çalışmalar, genetik araştırmalar etyolojinin kompleks bir yapıya sahip olduğunu göstermiş olmakla birlikte kalıcı tedavi planı oluşturulmasında pek bir fayda sağlayamamıştır. İlerleyen zamanlarda gen tedavileri veya kalmodulin, melatonin gibi bir takım moleküller üzerinden yapılacak tedaviler girişimsel olmayan ve kalıcı tedavileri gündeme getirebilir

Scoliosis Ethiopathonenesis: Changing Paradigms Through The Evidence

Scoliosis defined as side curvatures of the spine, is a deformity investigated since ancient times but without definitive findings. Although easily diagnosed clinically and radiologically, it's difficult to clarify the etiology and treatment. Many theories have been proposed regarding the etiology. However, studies at molecular level and genetic studies have shown complex etiology but not helped for a permanent treatment plan. Ahead of, treatment modalities concerning calmodulin, gene therapy or melatonin will revive non-invasive cures.

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