Behçet Hastalığında Nabız Dalga Hızı Aracılığı ile Değerlendirilen Azalmış Arteriyel Elastisite

Giriş: Behçet hastalığı, nadir görülen kronik bir hastalıktır. Başlıca histopatolojik lezyonu vaskülittir. Nabız dalga hızı aortik sertliğin göstergesi olup arteriyel distansibilite, elastisite ve göreceli arteriyel kompliyansla ters yönde ilişkilidir. Mevcut çalışmada; Behçet hastalığına sahip hastalarda nabız dalga hızı aracılığı ile ölçülen arteriyel elastisite araştırılmıştır. Hastalar ve Yöntem: Daha önce bilinen hipertansiyon, diabetes mellitus, hiperlipidemi gibi geleneksel kardiyovasküler risk faktörü olmayan 25 (21 erkek) Behçet hastası ve 21 (10 erkek) sağlıklı birey çalışmaya alındı. Ortalama hastalık süresi 3.6 ± 2.5 (1-10) yıldı. Arteriyel elastisite, otomatik olarak karotis-femoral (aortik) nabız dalga hızı aracılığıyla Complior Colson (Fransa) cihazı ile değerlendirildi. Nabız dalga hızı; Nabız dalga hızı (m/s) = mesafe (m)/ilerleme zamanı (s) formülü ile hesaplandı. Bulgular: Karotis-femoral (aortik) nabız dalga hızı (10.66 ± 1.74; 8.16 ± 0.84 m/s) ve diyastolik kan basıncı (79.00 ± 10.10; 73.33 ± 8.11 mmHg) kontrol grubuna göre Behçet hastalığında daha yüksek bulundu (sırası ile p< 0.001, p= 0.03). Sadece nabız dalga hızı ile yaş, diyastolik kan basıncı ve ortalama kan basıncı arasında anlamlı korelasyon saptandı (sırası ile p< 0.001, r= 0.56; p= 0.02, r= 0.32; p= 0.03, r= 0.31). Sonuç: Arteriyel sertlik ve aterosklerozun bir belirteci olan karotis-femoral (aortik) nabız dalga hızı aracılığı ile değerlendirilen arteriyel elastisite sağlıklı kontrollere göre Behçet hastalığında azalmış olarak bulunmuştur.

Anahtar Kelimeler:

Behçet hastalığı, nabız dalga hızı

Decreased Arterial Elasticity Assessed by Pulse Wave Velocity in Patients with Behçet’s Disease

Introduction: Behçet’s disease (BD) is a rare chronic disorder. The predominant histopathological lesion is vasculitis. Pulse wave velocity (PWV) is a marker of aortic stiffness and inversely related to arterial distensibility, elasticity, or relative arterial compliance. The aim of the present study was to investigate the arterial elasticity using PWV in patients with BD. Patients and Methods: A total of 25 patients with BD (21 male) and 21 healthy subjects (10 male) without known traditional cardiovascular risk factors, such as hypertension, diabetes mellitus, and hyperlipidemia, were studied. The mean time of disease duration was 3.6 ± 2.5 (1-10) years. Arterial elasticity was assessed by automatic carotid-femoral (aortic) PWV measurement by the Complior Colson (France) device. PWV is calculated by the following formula: Pulse wave velocity (m/s) = distance (m)/transit time (s). Results: The carotid-femoral (aortic) PWV (10.66 ± 1.74 vs. 8.16 ± 0.84 m/s) and diastolic blood pressure (79.00 ± 10.10 vs. 73.33 ± 8.11 mmHg) were higher in patients with BD than in the control groups (p< 0.001 and p= 0.03, respectively). A significant correlation was found between PWV and age, diastolic blood pressure, and mean blood pressure in the studied group (p< 0.001, r= 0.56; p= 0.02, r= 0.32; and p= 0.03, r= 0.31, respectively). Conclusion: Arterial elasticity assessed by carotid-femoral (aortic) PWV, an indicator of arterial stiffness and atherosclerosis, is lower in patients with BD than in healthy controls.

Keywords:

Behçet’s disease, pulse wave velocity,

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi