Gated Miyokard Perfüzyon Spect Çalışmasındaki Stres Defekt Skorları İle Homosistein Düzeylerinin Karşılaştırılması

Amaç: Ülkemizde Koroner Arter Hastalığı (KAH) prevalansı giderek artmakta ve önemli sağlık sorunlarından biri haline gelmektedir. GATED miyokard perfüzyon SPECT sintigrafisi KAH tanısı koymada ve prognozu öngörmede kullanılan non-invaziv, basit ve kolay bir tekniktir. Bu çalışmanın amacı GATED Miyokard Perfüzyon SPECT çalışmasında elde ettiğimiz stres defekt skorları ile homosistein (HCY) düzeyini karşılaştırmaktır.Yöntem: Kasım/2012-Mart–2013 tarihleri arasında KAH ön tanısı ile MPS için bölümümüze başvuran 166 hasta çalışmaya dahil edildi. 96 kadın, 70 erkek (ortalama yaş 56±11,6) çalışma grubunu oluşturdu. Hastalardan alınan kan örneklerinde ELISA metodu ile HCY seviyesi ölçüldü. Görsel olarak iskemi varlığı değerlendirildi. Sol ventriküle ait sayısal parametreler kantitatif GATED SPECT (QGS) yazılımı ile otomatik olarak elde edildi.Bulgular: Hastalar sintigrafi sonuçlarına göre 60 (%57,1)’ı normal, 45 (%42,9)’i iskemik olarak bulundu. Hastaların HCY düzeyleri normal olan grupta 16,36±9,7 μmol/L bulunurken, iskemik olan grupta 16,6±8,5 μmol/L bulundu (p=0,895). Sonuç: Çalışmamızda HCY düzeyi ile GATED miyokard perfüzyon SPECT çalışmasından elde ettiğimiz kardiyovasküler risk parametreleri arasında anlamlı bir ilişki bulunmamıştır.

Anahtar Kelimeler:

Koroner Arter Hastalığı, Homosistein, Myokard Perfüzyon Sintigrafisi

The Comparison of Homocysteine Levels with Stress Gated Myocardial Perfusion Defect Scores of the SPECT Study

Objective: In our country, the prevalence of Coronary Artery Disease (CAD) has been increasing and becoming one of the most important health problems. GATED SPECT myocardial perfusion scintigraphy is a non-invasive, simple and easy technique used in diagnosis and predicting prognosis of CAD. The aim of this study was to compare the level of Homocysteine (HCY) with stress defect scores that we obtained from GATED Myocardial Perfusion SPECT study. Methods: Between November 2012-March 2013, 166 patients with suspected coronary artery disease referred to our department for the myocardial perfusion scintigraphy included in this study. The study consisted of 96 women and 70 men (mean age 56±11,6). HCY levels were measured in blood samples by ELISA. The presence of ischemia was evaluated visually. The numerical parameters of the left ventricle was obtained automatically by the software quantitative gated SPECT (QGS). Results: According to the scintigraphic results, 60(%57,1) of the patients were normal and 45(%42,9) of the patients had ischemia. Mean HCY values of patients were found to be 16,36±9,7 μmol/L in normal group and 16,6±8,5 μmol/L in the ischemic group (p=0,895). Conclusion: We found no significant correlation between HCY levels and cardiovascular risk parameters obtained from GATED myocardial perfusion SPECT.

Keywords:

Coronary Artery Disease, Homocysteine, Myocardial Perfusion Scintigraphy,

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ISSN: 1309-3878
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2009
Yayıncı: Düzce Üniversitesi Tıp Fakültesi Aile Hekimliği AD adına Yrd.Doç.Dr.Cemil Işık Sönmez