Alt Ekstremite Venöz Tromboz Tedavisinde Yeni Oral Antikoagulanların Etkinliği: Retrospektif Klinik Çalışma

Amaç: Bu klinik çalışma alt ekstremite derin ven trombozu nedeniyle yeni oral antikoagulan ilaç (rivaroksaban, dabigatran,apiksaban, edoksaban) kullanan 138 hastanın retrospektif olarak incelenmesini içermektedir. Hastaların demografik özellikleri ile hastalık ilişkisi, tedavi başlangıç- bitiş süreleri, radyolojik ve klinik iyileşme durumları, yeni oral antikoagulanların yan etkileri değerlendirilmiştir. Metod: Retrospektif çalışmaya yeni oral antikoagulan ilaç kullanan 138 hasta dahil edildi. Hastaların demografik özellikleri, tanı ve tedavi şemaları, radyolojik görüntüleri, epikriz notları kayıt edildi. Her bir hastanın kayıtları takip edildikleri 12 ay boyunca incelendi. Yeni oral antikoagulan etkinliği; tedavi öncesi ve sonrası uyluk ve baldır çaplarının ölçülmesi, doppler USG’de rekanalizasyon olup olmadığı (rekanalizasyon>%75), rekanalizasyon süresi, kanama yan etkileri ve tedavi ile iyileşme süreleri, rekürrens oranları ölçülerek değerlendirildi. Veriler istatistik programı kullanılarak istatiksel olarak incelendi. Bulgular: Tedavi başlangıcında ölçülen uyluk çap ölçümleri ortalaması (Ort±SS:75,41 ) ile tedavi sonrası ölçülen uyluk çap ortalaması (Ort±SS:54,63) karşılaştırıldığında anlamlı fark bulundu. P

Anahtar Kelimeler:

Antikoagülan ajanlar, derin ven trombozu, trombofili

The Effectiveness of New Oral Anticoagulants in the Treatment of Lower Extremity Venous Thrombosis: A Retrospective Clinical Study

Objective: This clinical study included a retrospective evaluation of 138 patients using new oral anticoagulants (rivaroxaban, dabigatran, apixaban, edoxaban) for lower extremity deep vein thrombosis. The demographic characteristics of the patients and the relationship between the disease, treatment initiation and end times, radiological and clinical recovery, and NOACSSS side effects were evaluated. Materials and Method: 138 patients using new oral anticoagulant drugs were included in the retrospective study. Demographic characteristics, diagnosis and treatment charts, radiological images, epicrisis notes of the patients were recorded. Records of each patient were reviewed during their 12 months of follow-up. New oral anticoagulant efficacy; It was evaluated by measuring thigh and calf diameters before and after treatment, whether there was recanalization in Doppler USG (recanalization> 75%), recanalization time, bleeding side effects and recovery times with treatment, and recurrence rates. The data were analyzed statistically using a statistics program. Results: A significant difference was found when the mean thigh diameter measurements measured at the beginning of the treatment (Mean ± SD: 75,41) and the mean thigh diameter measured after the treatment (Mean ± SD: 54,63) were compared. P

Keywords:

New oral anticoagulants, deep vein thrombosis, thrombophilia,

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ISSN: 1309-3878
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2009
Yayıncı: Düzce Üniversitesi Tıp Fakültesi Aile Hekimliği AD adına Yrd.Doç.Dr.Cemil Işık Sönmez