EMİN ÖZLÜ, Ragıp ERTAŞ, Kemal ÖZYURT, İsmail KARAATLI, AYŞE SERAP KARADAĞ

Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi

Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris

Objective: We aimed to investigate the effect of isotretinoin treatment on sleep and quality of life in patients with AV. Methods: Sixty-six AV patients, who had attended the dermatology outpatient clinic and started isotretinoin treatment, and forty-three healthy controls, were enrolled in the study. Pittsburg Sleep Quality Index (PSQI), short form-36 (SF-36), and Global Acne Grading System (GAGS) were administered to all patients twice; before and two months after the treatment. The results were compared with the healthy control group. Results: The pretreatment physical health scores of the patients were significantly higher than the healthy controls. No significant differences were observed between before-after isotretinoin treatment regarding physical and mental health scores in AV patients. While there were no significant differences between the pretreatment and healthy control group in terms of total PSQI scores; the scores of sleep duration were significantly lower in the pretreatment group. No significant differences were observed between before-after isotretinoin treatment regarding total PSQI and subcomponent scores in AV patients. There was a statistically significant negative correlation between pre- and post-treatment total PSQI scores and physical, mental health scores in patients with AV. Conclusion: Results of the present study suggest that isotretinoin therapy does not affect the sleep quality in patients with AV. The impairment of sleep quality negatively affects the quality of life in patients with AV. More comprehensive studies assessing the effect of isotretinoin treatment on sleep quality are needed.

Keywords:

Acne vulgaris, isotretinoin, sleep disorders, quality of life,

PDF

___

1- Erturan İ, Aktepe E, Kocaman O, ve ark. Akneli Ergenlerin yaşam kalitesi, yalnızlık ve yaşam doyumu düzeylerinin değerlendirilmesi. Türkderm. 2014; 48: 172-6.
2- Karadag AS, Bilgili SG, Selvi Y, et al. Effects of isotretinoin treatment on general psychiatric symptoms, quality of life and social phobia in acne vulgaris patients. J Eur Acad Dermatol Venereol. 2013; 27:260-1.
3- Schrom K,Nagy T,Mostow E. Depression screening using health questionnaires in patients receiving oral isotretinoin for acne vulgaris. J Am Acad Dermatol. 2016; 75: 237-9.
4- Deveci E, Ozturk A, Kırpınar İ, et al. Akneli hastalarda izotretinoin kullanımı sırasında dikkat ve yürütücü işlevlerde düzelme. Türkderm. 2013; 47: 109-113.
5- McGrath EJ, Lowell CR, Gillison CR, et al. A prospective trial of the effects of isotretinoin on quality of life and depressive symptoms. Br J Dermatol. 2010; 163: 1323-1329.
6- Marron SE, Tomas-Aragones L, Boira S. Anxiety, depression, quality of life and patient satisfaction in acne patients treated with oral isotretinoin. Acta Derm Venereol. 2013; 93: 701-6.
7- Biçici F, Berksoy Hayta S, Akyol M, et al. Psoriasisli hastalarda uyku kalitesinin değerlendirilmesi. Türkderm. 2015; 49: 208-12.
8- Ismailogullari S, Ferahbas A, Aksu M, et al. Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study. J Eur Acad Dermatol Venereol. 2012; 26: 778-81.
9- Hanna KJ, Agnieszka KP, Michal D, et al. Affective disorders as potential complication of anti-acne treatment with isotretinoin: A case series. J Affect Disord. 2016; 204: 154-8.
10- Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997; 36: 416-8.
11- Ware JE, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992; 30: 473-83.
12- Agargün MY, Kara H, Anlar Ö. Pittsburgh Uyku kalitesi indeksinin geçerliliği ve güvenilirliği. Türk Psikiyatri Dergisi. 1996; 7: 107-15.
13- Türel Ertmertcan A. Akne ve yaşam Kalitesi. Dermatoz. 2007; 2: 91-97.
14- Cyrulnik AA, Viola KV, Gewirtzman AJ, et al. High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life. Int J Dermatol. 2012; 51: 1123-30.
15- Öztürkcan S, Aydemir Ö, Inanır I. Akne vulgarisli hastalarda yaşam kalitesi. T Klin Dermatoloji 2002; 12: 131-134.
16- Jones-Caballero M, Chren MM, Soler B, et al. Quality of life in mild to moderate acne: relationship to clinical severity and factors influencing change with treatment. J Eur Acad Dermatol Venereol 2007; 21: 219-226.
17- Zisapel N. Sleep and sleep disturbances: Biological basis and clinical implications. Cell Mol Life Sci 2007; 64: 1174-86.
18- Oyetakin-White P, Suggs A, Koo B, et al. Does poor sleep quality affect skin ageing? Clin Exp Dermatol. 2015; 40: 17-22.
19- Bilgiç Ö, Bilgiç A, Altinyazar HC. Relationship between sleep quality and facial sebum levels in women with acne vulgaris. Indian J Dermatol Venereol Leprol. 2016; 82: 313-4.
20- Smedje H, Schwan S, Hallberg E, et al. Onset of Kleine-Levin Syndrome in association with isotretinoin treatment. Acta Paediatr. 2010; 99: 946-8.
21- Shehi GM, Bryson WJ. Hypersomnia associated with isotretinoin in a patient with recurrent major depressive disorder and acne vulgaris. Sleep. 2004; 27: 821.

ISSN: 1309-3878
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2009
Yayıncı: Düzce Üniversitesi Tıp Fakültesi Aile Hekimliği AD adına Yrd.Doç.Dr.Cemil Işık Sönmez