Rat ve Farede Doğumda Yavru Sayısı ve Ana Ağırlığının Erken Dönem Büyüme Üzerine Etkisi

Araştırmada rat ve farelerde doğumda yavru sayısı ve ana ağırlığının erken dönem büyüme üzerine etkisi incelendi. Araştırma on dört haftalık 17 adet rat (Spraque Dawley) ve 20 adet fare (BALB/c) üzerinde yapıldı. Ana ve yavrular 3 haftalık yaşa kadar beraber tutuldu ve yavruların ana sütü almaları sağlandı. Doğan yavrular 1. gün ve 1, 2, 3, 4 ve 5 haftalık yaşlarda bireysel olarak tartıldı. Analar kafesten uzaklaştırıldıktan sonra yavru grupları aynı kafeste barındırıldı. Tüm hayvanlar aynı sıcaklık (23ºC) ve neme (%50) sahip kontrollü odada tutuldu, sabah 6.00 - akşam 6: 00 arasında ışık almaları sağlandı. Hayvanlar standart pelet rodent yemi ile beslendi (%18 ham protein ve 2600 kcal/kg metabolik enerji). Yem ve taze su ad libitum verildi. Faktörler ana etkileri ve birbirleri arasındaki interaksiyonlar için incelendi, modelde doğumda yavru sayısı ratta üç gruba (8, 9 ve 10’lu doğum) farede ise dört gruba ayrıldı (7, 8, 9 ve 10’lu doğum). Doğumda ana ağırlığı ratta

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The Effects of Litter-Size and Maternal Body Weight on Early Postnatal Growth in the Rat and Mouse

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